Q Chen1, F W Hetzel. 1. Research and Development, HealthONE, Denver, CO 80208, USA. junye@cris.com
Abstract
OBJECTIVE: To review the currently available data of photodynamic therapy (PDT) optical dosimetry for possible prostatic applications. SUMMARY BACKGROUND DATA: PDT is a new cancer treatment modality often used as an alternative tumor treatment method. Recently, PDT has been suggested as an alternative therapy for prostatic carcinoma and BPH. METHODS: PDT: utilizes light and a preadministered photosensitizer drug to achieve localized tumor control. This article reviews currently available data on optical dosimetry of PDT in both human and canine prostates. RESULTS: At 630 nm, a common wavelength used for Photofrin PDT, results indicate that light penetration is similar in cancerous and normal prostatic tissue. Because of limited light penetration, multiple fiber irradiation is necessary if eradicating the entire prostate glad is the ultimate goal. The available data also show that dynamic changes occur in light fluence rate distribution during PDT irradiation. CONCLUSIONS: PDT can be used to destroy prostatic tissue. Real-time optical dosimetry is necessary if accurate lesion volume control is desired.
OBJECTIVE: To review the currently available data of photodynamic therapy (PDT) optical dosimetry for possible prostatic applications. SUMMARY BACKGROUND DATA: PDT is a new cancer treatment modality often used as an alternative tumor treatment method. Recently, PDT has been suggested as an alternative therapy for prostatic carcinoma and BPH. METHODS: PDT: utilizes light and a preadministered photosensitizer drug to achieve localized tumor control. This article reviews currently available data on optical dosimetry of PDT in both human and canine prostates. RESULTS: At 630 nm, a common wavelength used for Photofrin PDT, results indicate that light penetration is similar in cancerous and normal prostatic tissue. Because of limited light penetration, multiple fiber irradiation is necessary if eradicating the entire prostate glad is the ultimate goal. The available data also show that dynamic changes occur in light fluence rate distribution during PDT irradiation. CONCLUSIONS: PDT can be used to destroy prostatic tissue. Real-time optical dosimetry is necessary if accurate lesion volume control is desired.
Authors: Zheng Huang; Qun Chen; Nadira Trncic; Susan M LaRue; Pierre-Hervé Brun; Brian C Wilson; Howard Shapiro; Fred W Hetzel Journal: Radiat Res Date: 2004-06 Impact factor: 2.841
Authors: Zheng Huang; Qun Chen; David Luck; Jill Beckers; Brian C Wilson; Nadira Trncic; Susan M Larue; Dominique Blanc; Fred W Hetzel Journal: Lasers Surg Med Date: 2005-06 Impact factor: 4.025