L H Canani1, F Gerchman, J L Gross. 1. Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Brazil.
Abstract
OBJECTIVE: To evaluate whether there is a familial association of arterial hypertension, coronary heart disease, renal disease, and stroke with diabetic nephropathy RESEARCH DESIGN AND METHODS: There were 115 outpatients and 34 patients with end-stage renal disease treated by hemodialysis (61 men, age range 41-81 years) and having at least one sibling with type 2 diabetes studied. The positive or negative history of siblings (n = 765) was assessed by a standard questionnaire. The urinary albumin excretion rate (UAER) was measured by radioimmunoassay in 24-h sterile urine (three samples). The subjects were grouped as normoalbuminuric (UAER <20 microg/min, n = 59), microalbuminuric (UAER 20-200 microg/min, n = 35), macroalbuminuric (UAER >200 microg/min, n = 21), and end-stage renal disease (n = 34). RESULTS: Patients with microalbuminuria, macroalbuminuria, or end-stage renal disease had an increased prevalence of sibling history of arterial hypertension (33.2, 37.3, and 33.8 vs. 23.4%, P < 0.001) and coronary heart disease (15.2, 17.0, and 19.4 vs. 10.2%, P = 0.044) compared with the normoalbuminuric group. The renal disease history was increased only in the siblings of patients with macroalbuminuria or end-stage renal disease (12.8 and 15.6 vs. 7.6 and 6.1%, P = 0.005). The presence of sibling arterial hypertension strongly increases the prevalence of sibling renal and coronary heart disease independent of patient renal status. CONCLUSIONS: There is an association of diabetic nephropathy and sibling history of arterial hypertension and renal and coronary heart disease in type 2 diabetic patients. These associations are not independent, and arterial hypertension may be their main determining factor.
OBJECTIVE: To evaluate whether there is a familial association of arterial hypertension, coronary heart disease, renal disease, and stroke with diabetic nephropathy RESEARCH DESIGN AND METHODS: There were 115 outpatients and 34 patients with end-stage renal disease treated by hemodialysis (61 men, age range 41-81 years) and having at least one sibling with type 2 diabetes studied. The positive or negative history of siblings (n = 765) was assessed by a standard questionnaire. The urinary albumin excretion rate (UAER) was measured by radioimmunoassay in 24-h sterile urine (three samples). The subjects were grouped as normoalbuminuric (UAER <20 microg/min, n = 59), microalbuminuric (UAER 20-200 microg/min, n = 35), macroalbuminuric (UAER >200 microg/min, n = 21), and end-stage renal disease (n = 34). RESULTS:Patients with microalbuminuria, macroalbuminuria, or end-stage renal disease had an increased prevalence of sibling history of arterial hypertension (33.2, 37.3, and 33.8 vs. 23.4%, P < 0.001) and coronary heart disease (15.2, 17.0, and 19.4 vs. 10.2%, P = 0.044) compared with the normoalbuminuric group. The renal disease history was increased only in the siblings of patients with macroalbuminuria or end-stage renal disease (12.8 and 15.6 vs. 7.6 and 6.1%, P = 0.005). The presence of sibling arterial hypertension strongly increases the prevalence of sibling renal and coronary heart disease independent of patient renal status. CONCLUSIONS: There is an association of diabetic nephropathy and sibling history of arterial hypertension and renal and coronary heart disease in type 2 diabeticpatients. These associations are not independent, and arterial hypertension may be their main determining factor.
Authors: Adriana M Hung; Dana C Crawford; Marie R Griffin; Kristin Brown-Gentry; Michael S Lipkowitz; Edward D Siew; Kerri Cavanaugh; Julia B Lewis; T Alp Ikizler Journal: Clin J Am Soc Nephrol Date: 2009-12-03 Impact factor: 8.237
Authors: Marjoriê P Buffon; Mariana P Carpena; Denise A Sortica; Andressa Santer; Rodrigo Carlessi; Bianca M de Souza; Maria I Edelweiss; Milton Berger; Daisy Crispim; Luís H Canani Journal: Diabetol Metab Syndr Date: 2016-01-08 Impact factor: 3.320