Literature DB >> 9726840

Augmented intrathecal secretion of interferon-gamma in response to Borrelia garinii in neuroborreliosis.

C Ekerfelt1, J Ernerudh, P Forsberg, S Bergström.   

Abstract

The Lyme disease agent Borrelia garinii has been suggested to be neurotrop, preferentially affecting the nervous system. We compared the secretion of interferon-gamma in response to outer surface proteins from Borrelia garinii and Borrelia afzelii in 10 patients with neuroborreliosis. In cerebrospinal fluid, stimulation with Borrelia garinii revealed higher numbers of interferon-gamma-secreting cells in all patients, whereas in blood, only five displayed higher numbers. This further strengthens the hypothesis of Borrelia garinii being associated with the development of neuroborreliosis.

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Year:  1998        PMID： 9726840     DOI： 10.1016/s0165-5728(98)00136-2

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  5 in total

1.  Mercury exposure as a model for deviation of cytokine responses in experimental Lyme arthritis: HgCl2 treatment decreases T helper cell type 1-like responses and arthritis severity but delays eradication of Borrelia burgdorferi in C3H/HeN mice.

Authors:  C Ekerfelt; M Andersson; A Olausson; S Bergström; P Hultman
Journal:  Clin Exp Immunol       Date:  2007-08-02       Impact factor: 4.330

2.  Reduced number of interleukin-12 secreting cells in patients with Lyme borreliosis previously exposed to Anaplasma phagocytophilum.

Authors:  S Jarefors; M Karlsson; P Forsberg; I Eliasson; J Ernerudh; C Ekerfelt
Journal:  Clin Exp Immunol       Date:  2006-02       Impact factor: 4.330

3.  Toward a better understanding of European lyme neuroborreliosis.

Authors:  Gary P Wormser; John J Halperin
Journal:  Clin Infect Dis       Date:  2013-05-10       Impact factor: 9.079

4.  Innate immune responses in Lyme borreliosis: enhanced tumour necrosis factor-alpha and interleukin-12 in asymptomatic individuals in response to live spirochetes.

Authors:  J Sjöwall; A Carlsson; O Vaarala; S Bergström; J Ernerudh; P Forsberg; C Ekerfelt
Journal:  Clin Exp Immunol       Date:  2005-07       Impact factor: 4.330

5.  Can ELISPOT Be Applied to A Clinical Setting as A Diagnostic Utility for Neuroborreliosis?

Authors:  Marika Nordberg; Pia Forsberg; Dag Nyman; Barbro H Skogman; Clara Nyberg; Jan Ernerudh; Ingvar Eliasson; Christina Ekerfelt
Journal:  Cells       Date:  2012-06-08       Impact factor: 6.600
  5 in total

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