Literature DB >> 9726820

Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease.

N J Karandikar1, C L Vanderlugt, J A Bluestone, S D Miller.   

Abstract

The B7/CD28:CTLA-4 costimulatory pathway plays a critical role in determining the fate of immune responses (activation vs. down-regulation) and is a highly promising therapeutic target for treating autoimmune diseases. In this review, we highlight the mechanisms by which this costimulatory pathway operates emphasizing the role of the different components in the pathogenesis of relapsing experimental autoimmune encephalomyelitis, a CD4 T cell-mediated autoimmune model of multiple sclerosis. The separate and distinct roles of B7-1, B7-2 and CTLA-4 in positive and negative regulation of autoimmune pathogenesis are considered and a working model is proposed.

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Year:  1998        PMID： 9726820     DOI： 10.1016/s0165-5728(98)00058-7

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  14 in total

1.  CD28 costimulatory blockade exacerbates disease severity and accelerates epitope spreading in a virus-induced autoimmune disease.

Authors:  K L Neville; M C Dal Canto; J A Bluestone; S D Miller
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

2.  Allogenic donor splenocytes pretreated with antisense peptide against B7 prolong cardiac allograft survival.

Authors:  J Chen; Q He; R Zhang; Y Chu; Y Wang; Q Liu; S Xiong
Journal:  Clin Exp Immunol       Date:  2004-11       Impact factor: 4.330

3.  Targeting of myelin protein zero in a spontaneous autoimmune polyneuropathy.

Authors:  Hye-Jung Kim; Cha-Gyun Jung; Mark A Jensen; Danuta Dukala; Betty Soliven
Journal:  J Immunol       Date:  2008-12-15       Impact factor: 5.422

Review 4.  The critical role of antigen-presentation-induced cytokine crosstalk in the central nervous system in multiple sclerosis and experimental autoimmune encephalomyelitis.

Authors:  Rebecca A Sosa; Thomas G Forsthuber
Journal:  J Interferon Cytokine Res       Date:  2011-09-15       Impact factor: 2.607

5.  Enhanced B7 costimulatory molecule expression in inflammatory human sural nerve biopsies.

Authors:  R Kiefer; F Dangond; M Mueller; K V Toyka; D A Hafler; H P Hartung
Journal:  J Neurol Neurosurg Psychiatry       Date:  2000-09       Impact factor: 10.154

Review 6.  The neuroimmunology of multiple sclerosis: possible roles of T and B lymphocytes in immunopathogenesis.

Authors:  K C O'Connor; A Bar-Or; D A Hafler
Journal:  J Clin Immunol       Date:  2001-03       Impact factor: 8.317

Review 7.  Prospects for antigen-specific tolerance based therapies for the treatment of multiple sclerosis.

Authors:  Danielle M Turley; Stephen D Miller
Journal:  Results Probl Cell Differ       Date:  2010

8.  Role of CD28 in fatal autoimmune disorder in scurfy mice.

Authors:  Nagendra Singh; Phillip R Chandler; Yoichi Seki; Babak Baban; Mayuko Takezaki; David J Kahler; David H Munn; Christian P Larsen; Andrew L Mellor; Makio Iwashima
Journal:  Blood       Date:  2007-04-26       Impact factor: 22.113

9.  Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy.

Authors:  Barbara Seitz-Polski; Guillaume Dolla; Christine Payré; Christophe A Girard; Joel Polidori; Kevin Zorzi; Eléonore Birgy-Barelli; Perrine Jullien; Cécile Courivaud; Thierry Krummel; Sylvia Benzaken; Ghislaine Bernard; Stéphane Burtey; Christophe Mariat; Vincent L M Esnault; Gérard Lambeau
Journal:  J Am Soc Nephrol       Date:  2015-11-13       Impact factor: 10.121

Review 10.  Costimulation: critical pathways in the immunologic regulation of asthma.

Authors:  Abdelouahab Bellou; Patricia W Finn
Journal:  Curr Allergy Asthma Rep       Date:  2005-03       Impact factor: 4.919
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