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Literature DB >> 9726281

Confirmation of quantitative trait loci for alcohol preference in mice.

L M Tarantino¹, G E McClearn, L A Rodriguez, R Plomin.

Abstract

An F2 intercross derived from C57BL/6 and DBA/2 progenitor inbred strains was used to test for replication of quantitative trait loci (QTLs) for alcohol preference nominated by a previous study using BXD recombinant inbred (RI) strains (Rodriguez et al., Alcohol. Clin. Exp. Res. 19:367-379, 1995). Fourteen provisional QTLs were nominated in the original RI study with a p < 0.05 criterion. In the present study, a genome scan (101 microsatellite markers) was conducted on an F2 population (n = 218). Three significant QTLs were detected on chromosomes 1, 4, and 9, and three suggestive QTLs were detected on chromosomes 2, 3, and 10. Of these six QTLs, four were consistent with the previous RI nominations. The replication rate of 28.6% (4 of 14) is in agreement with the results of simulation studies performed by Belknap et al. (Behav. Genet. 26:149-160, 1996) and supports the methodological argument for a multistage research design for nominating and replicating QTLs.

Entities: Chemical Gene Species

Mesh：

Year: 1998 PMID： 9726281

Source DB: PubMed Journal: Alcohol Clin Exp Res ISSN： 0145-6008 Impact factor: 3.455

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Cited

36 in total

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3. Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice.

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4. Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences.

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9. Genetic analysis of alcohol intake in recombinant inbred and congenic strains derived from A/J and C57BL/6J progenitors.

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Confirmation of quantitative trait loci for alcohol preference in mice.

Review 1. Pharmacogenetic studies of alcohol self-administration and withdrawal.

Review 2. Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction.

3. Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice.

4. Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences.

5. Linkage analyses of stimulant dependence, craving, and heavy use in American Indians.

6. Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.

Review 7. Genetic factors influencing alcohol dependence.

8. Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol.

9. Genetic analysis of alcohol intake in recombinant inbred and congenic strains derived from A/J and C57BL/6J progenitors.

10. Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross.