Literature DB >> 9723034

Nonsyntenic amplification of MYC with CDK4 and MDM2 in a malignant mixed tumor of salivary gland.

P H Rao1, V V Murty, D C Louie, R S Chaganti.   

Abstract

Karyotypic analysis of a metastatic malignant mixed tumor of the salivary gland revealed the presence of double minute chromosomes (dmin), indicative of gene amplification. Comparative genomic hybridization analysis of DNA extracted from the primary and a renal metastasis indicated overt amplification of DNA sequences derived from 8q23-24 and 12q13-15 regions. Subsequent Southern blot analysis of tumor DNA from the metastasis with the use of probes previously mapped to those regions indicated amplification of MYC at 8q23-24 and CDK4 and MDM2 at 12q13-15. Fluorescence in situ hybridization of differentially labeled MYC and MDM2 genes hybridized to tumor metaphase chromosomes revealed an independent nonsyntenic amplification of MYC and MDM2 on dmin in this tumor.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9723034     DOI： 10.1016/s0165-4608(98)00013-2

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  10 in total

1.  Alterations associated with androgen receptor gene activation in salivary duct carcinoma of both sexes: potential therapeutic ramifications.

Authors:  Yoshitsugu Mitani; Pulivarthi H Rao; Sankar N Maity; Yu-Chen Lee; Renata Ferrarotto; Julian C Post; Lisa Licitra; Scott M Lippman; Merrill S Kies; Randal S Weber; Carlos Caulin; Sue-Hwa Lin; Adel K El-Naggar
Journal:  Clin Cancer Res       Date:  2014-10-14       Impact factor: 12.531

2.  Reciprocal and Autonomous Glucocorticoid and Androgen Receptor Activation in Salivary Duct Carcinoma.

Authors:  Yoshitsugu Mitani; Sue-Hwa Lin; Kristen B Pytynia; Renata Ferrarotto; Adel K El-Naggar
Journal:  Clin Cancer Res       Date:  2019-11-26       Impact factor: 12.531

3.  Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma.

Authors:  Eva Röijer; Anders Nordkvist; Anna-Karin Ström; Walter Ryd; Margareta Behrendt; Jörn Bullerdiek; Joachim Mark; Göran Stenman
Journal:  Am J Pathol       Date:  2002-02       Impact factor: 4.307

4.  Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy.

Authors:  Pierre Saintigny; Yoshitsugu Mitani; Kristen B Pytynia; Renata Ferrarotto; Dianna B Roberts; Randal S Weber; Merrill S Kies; Sankar N Maity; Sue-Hwa Lin; Adel K El-Naggar
Journal:  Cancer       Date:  2018-10-05       Impact factor: 6.860

5.  [Molecular markers in salivary gland tumors: their use in diagnostic and prognostic workup].

Authors:  A Fehr; G Stenman; J Bullerdiek; T Löning
Journal:  Pathologe       Date:  2009-11       Impact factor: 1.011

6.  Overexpression of Tetraspanin31 contributes to malignant potential and poor outcomes in gastric cancer.

Authors:  Yusuke Takashima; Shuhei Komatsu; Takuma Ohashi; Jun Kiuchi; Hajime Kamiya; Hiroki Shimizu; Tomohiro Arita; Hirotaka Konishi; Atsushi Shiozaki; Takeshi Kubota; Kazuma Okamoto; Hitoshi Fujiwara; Hitoshi Tsuda; Eigo Otsuji
Journal:  Cancer Sci       Date:  2022-04-01       Impact factor: 6.518

Review 7.  Chromosome Translocations, Gene Fusions, and Their Molecular Consequences in Pleomorphic Salivary Gland Adenomas.

Authors:  Göran Stenman; Andre Fehr; Alena Skálová; Vincent Vander Poorten; Henrik Hellquist; Lauge Hjorth Mikkelsen; Nabil F Saba; Orlando Guntinas-Lichius; Carlos Miguel Chiesa-Estomba; Mattias K Andersson; Alfio Ferlito
Journal:  Biomedicines       Date:  2022-08-14

8.  Oncocytic change in pleomorphic adenoma: molecular evidence in support of an origin in neoplastic cells.

Authors:  Silvana Di Palma; Maryou B K Lambros; Kay Savage; Chris Jones; Alan Mackay; Tim Dexter; Marjan Iravani; Kerry Fenwick; Alan Ashworth; Jorge S Reis-Filho
Journal:  J Clin Pathol       Date:  2006-02-07       Impact factor: 3.411

Review 9.  Amplification of Cellular Oncogenes in Solid Tumors.

Authors:  Ozkan Bagci; Serkan Kurtgöz
Journal:  N Am J Med Sci       Date:  2015-08

Review 10.  Particular aspects in the cytogenetics and molecular biology of salivary gland tumours - current review of reports.

Authors:  Aleksandra J Ochal-Choińska; Ewa Osuch-Wójcikiewicz
Journal:  Contemp Oncol (Pozn)       Date:  2016-09-05
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.