| Literature DB >> 9722048 |
N A Hanley1, J P Bourke, A D Gascoigne.
Abstract
Flecainide acetate is a potent class Ic anti-arrhythmic drug with major sodium channel blocking actions. On the surface electrocardiogram this results in QTc interval prolongation. Overdose with class Ic drugs (< 0.1% of total intoxications) is uncommon, but management is difficult and the mortality high [1]. Serious flecainide overdose is characterised by ventricular tachyarrhythmias, severe bradycardia and variable degrees of atrioventricular block. This report describes a case of life-threatening flecainide overdose in a previously fit individual, resulting in a combination of cardiac disturbances. The treatment options and management are discussed.Entities:
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Year: 1998 PMID: 9722048 DOI: 10.1007/s001340050655
Source DB: PubMed Journal: Intensive Care Med ISSN: 0342-4642 Impact factor: 17.440