Literature DB >> 9722048

Survival in a case of life-threatening flecainide overdose.

N A Hanley1, J P Bourke, A D Gascoigne.   

Abstract

Flecainide acetate is a potent class Ic anti-arrhythmic drug with major sodium channel blocking actions. On the surface electrocardiogram this results in QTc interval prolongation. Overdose with class Ic drugs (< 0.1% of total intoxications) is uncommon, but management is difficult and the mortality high [1]. Serious flecainide overdose is characterised by ventricular tachyarrhythmias, severe bradycardia and variable degrees of atrioventricular block. This report describes a case of life-threatening flecainide overdose in a previously fit individual, resulting in a combination of cardiac disturbances. The treatment options and management are discussed.

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Year:  1998        PMID: 9722048     DOI: 10.1007/s001340050655

Source DB:  PubMed          Journal:  Intensive Care Med        ISSN: 0342-4642            Impact factor:   17.440


  7 in total

1.  Clinical course and outcome in class IC antiarrhythmic overdose.

Authors:  C Köppel; U Oberdisse; G Heinemeyer
Journal:  J Toxicol Clin Toxicol       Date:  1990

Review 2.  Antiarrhythmic drug effects on left ventricular performance.

Authors:  J P Bourke; J C Cowan; S Tansuphaswadikul; R W Campbell
Journal:  Eur Heart J       Date:  1987-03       Impact factor: 29.983

3.  Flecainide-induced QT prolongation and ventricular tachycardia.

Authors:  H K Lui; G Lee; P Dietrich; R I Low; D T Mason
Journal:  Am Heart J       Date:  1982-04       Impact factor: 4.749

4.  Life-threatening flecainide toxicity. A pharmacodynamic approach.

Authors:  B R Winkelmann; H Leinberger
Journal:  Ann Intern Med       Date:  1987-06       Impact factor: 25.391

5.  Persistent electrocardiographic changes after flecainide overdose.

Authors:  J Greig; B M Groden
Journal:  Br J Clin Pract       Date:  1995 Jul-Aug

6.  The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone.

Authors:  J T Lee; H K Kroemer; D J Silberstein; C Funck-Brentano; M D Lineberry; A J Wood; D M Roden; R L Woosley
Journal:  N Engl J Med       Date:  1990-06-21       Impact factor: 91.245

7.  [A case of acute voluntary poisoning with flecainide in a suicide attempt].

Authors:  L Anselmi; G Benza; V Nurra; G Derchi; R P Nicolino
Journal:  G Ital Cardiol       Date:  1987-08
  7 in total
  3 in total

1.  A case of near-fatal flecainide overdose in a neonate successfully treated with sodium bicarbonate.

Authors:  David H Jang; Robert S Hoffman; Lewis S Nelson
Journal:  J Emerg Med       Date:  2012-09-13       Impact factor: 1.484

2.  Successful treatment of flecainide overdose with sustained mechanical circulatory support.

Authors:  Anant Mandawat; Stephen A McCullough; Lauren G Gilstrap; Robert W Yeh
Journal:  HeartRhythm Case Rep       Date:  2015-04-17

3.  Flecainide Toxicity Secondary to Accidental Overdose: A Pediatric Case Report of Two Brothers.

Authors:  Sarah E Gardner Yelton; James B Leonard; Caridad M de la Uz; Rajeev S Wadia; Sean S Barnes
Journal:  Case Rep Crit Care       Date:  2021-05-13
  3 in total

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