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Literature DB >> 9721323

The pcd gene encoding piperideine-6-carboxylate dehydrogenase involved in biosynthesis of alpha-aminoadipic acid is located in the cephamycin cluster of Streptomyces clavuligerus.

F J Pérez-Llarena¹, A Rodríguez-García, F J Enguita, J F Martín, P Liras.

Abstract

Three open reading frames (ORFs) have been located downstream of cefE in the cephamycin C gene cluster of Streptomyces clavuligerus. ORF13 (pcd) encodes a 496-amino-acid protein (molecular weight [MW], 52,488) with an N-terminal amino acid sequence identical to that of pure piperideine-6-carboxylate dehydrogenase. ORF14 (cmcT) encodes a 523-amino-acid protein (MW, 54,232) analogous to Streptomyces proteins for efflux and resistance to antibiotics. ORF15 (pbp74) encodes a high molecular weight penicillin-binding protein (MW, 74, 094).

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Year: 1998 PMID： 9721323 PMCID： PMC107495

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

16 in total

1. The bla gene of the cephamycin cluster of Streptomyces clavuligerus encodes a class A beta-lactamase of low enzymatic activity.

Authors: F Pérez-Llarena; J F Martín; M Galleni; J J Coque; J L Fuente; J M Frère; P Liras
Journal: J Bacteriol Date: 1997-10 Impact factor: 3.490

Review 2. Proton-dependent multidrug efflux systems.

Authors: I T Paulsen; M H Brown; R A Skurray
Journal: Microbiol Rev Date: 1996-12

3. Molecular analysis of a beta-lactam resistance gene encoded within the cephamycin gene cluster of Streptomyces clavuligerus.

Authors: A S Paradkar; K A Aidoo; A Wong; S E Jensen
Journal: J Bacteriol Date: 1996-11 Impact factor: 3.490

4. Organization of a Clostridium thermocellum gene cluster encoding the cellulosomal scaffolding protein CipA and a protein possibly involved in attachment of the cellulosome to the cell surface.

Authors: T Fujino; P Béguin; J P Aubert
Journal: J Bacteriol Date: 1993-04 Impact factor: 3.490

5. Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.

Authors: J L de La Fuente; A Rumbero; J F Martín; P Liras
Journal: Biochem J Date: 1997-10-01 Impact factor: 3.857

6. An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.

Authors: E Fernández; F Lombó; C Méndez; J A Salas
Journal: Mol Gen Genet Date: 1996-07-26

7. Characterization of a Bacillus subtilis sporulation operon that includes genes for an RNA polymerase sigma factor and for a putative DD-carboxypeptidase.

Authors: J J Wu; R Schuch; P J Piggot
Journal: J Bacteriol Date: 1992-08 Impact factor: 3.490

8. xP2, a new member of the P-domain peptide family of potential growth factors, is synthesized in Xenopus laevis skin.

Authors: F Hauser; C Roeben; W Hoffmann
Journal: J Biol Chem Date: 1992-07-15 Impact factor: 5.157

9. Penicillin-binding proteins in Streptomyces cacaoi and Streptomyces clavuligerus. Kinetics of [13C]benzylpenicillin binding, temperature sensitivity and release of [14C]benzylpenicillin from the complex.

Authors: S Horikawa; H Nakazawa; H Ogawara
Journal: J Antibiot (Tokyo) Date: 1980-11 Impact factor: 2.649

10. Bacillus subtilis genome project: cloning and sequencing of the 97 kb region from 325 degrees to 333 degrees.

Authors: P Glaser; F Kunst; M Arnaud; M P Coudart; W Gonzales; M F Hullo; M Ionescu; B Lubochinsky; L Marcelino; I Moszer
Journal: Mol Microbiol Date: 1993-10 Impact factor: 3.501

17 in total

1. Early cephamycin biosynthetic genes are expressed from a polycistronic transcript in Streptomyces clavuligerus.

Authors: D C Alexander; M J Brumlik; L Lee; S E Jensen
Journal: J Bacteriol Date: 2000-01 Impact factor: 3.490

Review 2. Avoidance of suicide in antibiotic-producing microbes.

Authors: Eric Cundliffe; Arnold L Demain
Journal: J Ind Microbiol Biotechnol Date: 2010-05-06 Impact factor: 3.346

3. Mycobacterium avium genes associated with the ability to form a biofilm.

Authors: Yoshitaka Yamazaki; Lia Danelishvili; Martin Wu; Molly Macnab; Luiz E Bermudez
Journal: Appl Environ Microbiol Date: 2006-01 Impact factor: 4.792

4. Applications of gene replacement technology to Streptomyces clavuligerus strain development for clavulanic acid production.

Authors: A S Paradkar; R H Mosher; C Anders; A Griffin; J Griffin; C Hughes; P Greaves; B Barton; S E Jensen
Journal: Appl Environ Microbiol Date: 2001-05 Impact factor: 4.792

5. Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an omega-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the omega-aminotransferase.

Authors: E M Martín de Valmaseda; S Campoy; L Naranjo; J Casqueiro; J F Martín
Journal: Mol Genet Genomics Date: 2005-10-20 Impact factor: 3.291

6. CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus.

Authors: Irene Santamarta; Antonio Rodríguez-García; Rosario Pérez-Redondo; Juan F Martín; Paloma Liras
Journal: J Bacteriol Date: 2002-06 Impact factor: 3.490

7. Inducing effect of diamines on transcription of the cephamycin C genes from the lat and pcbAB promoters in Nocardia lactamdurans.

Authors: A L Leitão; F J Enguita; J L De La Fuente; P Liras; J F Martin
Journal: J Bacteriol Date: 1999-04 Impact factor: 3.490