Literature DB >> 9720322

Apoptosis regulation and its applications to biotechnology.

A J Dickson1.   

Abstract

Increased knowledge of the molecular interactions that characterize the control of apoptosis is identifying possible novel approaches to inhibit cell death and generate enhanced viable cell biomass. The application of such approaches to recombinant mammalian cells promises to improve the cost-effectiveness of industrial-scale protein expression.

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Year:  1998        PMID: 9720322     DOI: 10.1016/s0167-7799(98)01183-4

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN: 0167-7799            Impact factor:   19.536


  2 in total

1.  Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation.

Authors:  M Fussenegger; D Fassnacht; R Schwartz; J A Zanghi; M Graf; J E Bailey; R Pörtner
Journal:  Cytotechnology       Date:  2000-01       Impact factor: 2.058

2.  Prolongation of murine hybridoma cell survival in stationary batch culture by Bcl-xL expression.

Authors:  J R Charbonneau; E R Gauthier
Journal:  Cytotechnology       Date:  2000-10       Impact factor: 2.058

  2 in total

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