| Literature DB >> 9719605 |
J M Janusz1, P A Young, J M Ridgeway, M W Scherz, K Enzweiler, L I Wu, L Gan, J Chen, D E Kellstein, S A Green, J L Tulich, T Rosario-Jansen, I J Magrisso, K R Wehmeyer, D L Kuhlenbeck, T H Eichhold, R L Dobson.
Abstract
We report an expansion of the scope of our initial discovery that 5-keto-substituted 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofurans (DHDMBFs) are antiinflammatory and analgesic agents. Several other functional groups have been introduced at the 5 position: amides, amidines, ureas, guanidines, amines, heterocycles, heteroaromatics, and heteroaryl ethenyl substituents in the 5 position all provide active compounds. These compounds are dual cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitors. They inhibit both COX-1 and COX-2 with up to 33-fold selectivity for COX-2.Entities:
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Year: 1998 PMID： 9719605 DOI： 10.1021/jm9802416
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446