Literature DB >> 9718088

Appetite suppression and weight loss after the cannabinoid antagonist SR 141716.

G Colombo1, R Agabio, G Diaz, C Lobina, R Reali, G L Gessa.   

Abstract

The effect of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716 (2.5 and 10 mg/kg; i.p.) reduced dose-dependently both food intake and body weight. Tolerance to the anorectic effect developed within 5 days; in contrast, body weight in SR 141716-treated rats remained markedly below that of vehicle-treated rats throughout the entire treatment period (14 days). The results suggest that brain cannabinoid receptors are involved in the regulation of appetite and body weight.

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Year:  1998        PMID： 9718088     DOI： 10.1016/s0024-3205(98)00322-1

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  120 in total

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