W Smith1, P Mitchell. 1. National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory.
Abstract
PURPOSE: To assess the associations between stages of age-related maculopathy (ARM) and reported family history of this eye disease. METHODS: A cross-sectional study of 3654 subjects from a defined geographical area west of Sydney (NSW, Australia) identified subjects with late age-related macular degeneration (AMD) and early ARM from masked detailed grading of retinal photographs. Interviewer-administered questionnaires provided data on family history of ARM. Logistic regression was used to assess associations, adjusting for other known risk factors. RESULTS: A family history of ARM was significantly associated with both late AMD (odds ratio (OR) 3.92; 95% confidence interval (CI) 1.34-11.46) and early ARM (OR 2.17; 95% CI 1.04-4.55). The association was highest for neovascular AMD. CONCLUSIONS: These findings provide persuasive evidence that a stated family history of ARM is an important risk factor for ARM.
PURPOSE: To assess the associations between stages of age-related maculopathy (ARM) and reported family history of this eye disease. METHODS: A cross-sectional study of 3654 subjects from a defined geographical area west of Sydney (NSW, Australia) identified subjects with late age-related macular degeneration (AMD) and early ARM from masked detailed grading of retinal photographs. Interviewer-administered questionnaires provided data on family history of ARM. Logistic regression was used to assess associations, adjusting for other known risk factors. RESULTS: A family history of ARM was significantly associated with both late AMD (odds ratio (OR) 3.92; 95% confidence interval (CI) 1.34-11.46) and early ARM (OR 2.17; 95% CI 1.04-4.55). The association was highest for neovascular AMD. CONCLUSIONS: These findings provide persuasive evidence that a stated family history of ARM is an important risk factor for ARM.
Authors: Nathan G Lambert; Hanan ElShelmani; Malkit K Singh; Fiona C Mansergh; Michael A Wride; Maximilian Padilla; David Keegan; Ruth E Hogg; Balamurali K Ambati Journal: Prog Retin Eye Res Date: 2016-05-06 Impact factor: 21.198
Authors: Anna-Maija Tolppanen; Tanja Nevalainen; Marjukka Kolehmainen; Sanna Seitsonen; Ilkka Immonen; Matti Uusitupa; Kai Kaarniranta; Leena Pulkkinen Journal: Mol Vis Date: 2009-04-15 Impact factor: 2.367