Literature DB >> 9714798

Molecular cloning of mouse choline kinase and choline/ethanolamine kinase: their sequence comparison to the respective rat homologs.

C Aoyama1, K Nakashima, K Ishidate.   

Abstract

Complementary DNAs homologous to a rat 42-kDa choline/ethanolamine kinase [C. Aoyama et al., Biochim. Biophys. Acta 1390 (1998) 1-7] and to a 50-kDa choline kinase [T. Uchida and S. Yamashita, J. Biol. Chem. 267 (1992) 10156-10162] were isolated from a 17-day post coitum mouse embryo cDNA library and their sequences were compared with the two murine species, respectively. The nucleotide sequence homology (within the coding sequence) between mouse and rat 50-kDa choline kinases (96.0%) was considerably higher than that between their 42-kDa choline/ethanolamine kinases (92.4%). Northern blot and RT-PCR studies on several rat tissues demonstrated that both isozymes are expressed ubiquitously with the highest level in testis.

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Year:  1998        PMID： 9714798     DOI： 10.1016/s0005-2760(98)00062-9

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  Choline kinase beta is required for normal endochondral bone formation.

Authors:  Zhuo Li; Gengshu Wu; Roger B Sher; Zohreh Khavandgar; Martin Hermansson; Gregory A Cox; Michael R Doschak; Monzur Murshed; Frank Beier; Dennis E Vance
Journal:  Biochim Biophys Acta       Date:  2014-03-14

Review 2.  Choline metabolism-based molecular diagnosis of cancer: an update.

Authors:  Kristine Glunde; Marie-France Penet; Lu Jiang; Michael A Jacobs; Zaver M Bhujwalla
Journal:  Expert Rev Mol Diagn       Date:  2015-04-28       Impact factor: 5.225

3.  Expression and characterization of the active molecular forms of choline/ethanolamine kinase-alpha and -beta in mouse tissues, including carbon tetrachloride-induced liver.

Authors:  Chieko Aoyama; Akiko Ohtani; Kozo Ishidate
Journal:  Biochem J       Date:  2002-05-01       Impact factor: 3.857

4.  Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.

Authors:  Bum Soo Hong; Abdellah Allali-Hassani; Wolfram Tempel; Patrick J Finerty; Farrell Mackenzie; Svetoslav Dimov; Masoud Vedadi; Hee-Won Park
Journal:  J Biol Chem       Date:  2010-03-18       Impact factor: 5.157

Review 5.  Choline kinase alpha-Putting the ChoK-hold on tumor metabolism.

Authors:  Sean P Arlauckas; Anatoliy V Popov; E James Delikatny
Journal:  Prog Lipid Res       Date:  2016-04-09       Impact factor: 16.195

Review 6.  Targeting Phospholipid Metabolism in Cancer.

Authors:  Menglin Cheng; Zaver M Bhujwalla; Kristine Glunde
Journal:  Front Oncol       Date:  2016-12-27       Impact factor: 6.244

7.  Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment.

Authors:  David Gallego-Ortega; Ana Ramirez de Molina; Maria Angeles Ramos; Fatima Valdes-Mora; Maria Gonzalez Barderas; Jacinto Sarmentero-Estrada; Juan Carlos Lacal
Journal:  PLoS One       Date:  2009-11-12       Impact factor: 3.240

8.  Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1).

Authors:  Santiago Schiaffino-Ortega; Eleonora Baglioni; Elena Mariotto; Roberta Bortolozzi; Lucía Serrán-Aguilera; Pablo Ríos-Marco; M Paz Carrasco-Jimenez; Miguel A Gallo; Ramon Hurtado-Guerrero; Carmen Marco; Giuseppe Basso; Giampietro Viola; Antonio Entrena; Luisa Carlota López-Cara
Journal:  Sci Rep       Date:  2016-03-31       Impact factor: 4.379

9.  Phosphorylation of Human Choline Kinase Beta by Protein Kinase A: Its Impact on Activity and Inhibition.

Authors:  Ching Ching Chang; Ling Ling Few; Manfred Konrad; Wei Cun See Too
Journal:  PLoS One       Date:  2016-05-05       Impact factor: 3.240
  9 in total

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