Literature DB >> 9714598

RAP, a novel type of ER chaperone.

G Bu1, A L Schwartz.   

Abstract

Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.

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Year:  1998        PMID： 9714598     DOI： 10.1016/s0962-8924(98)01283-5

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  28 in total

1.  Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation.

Authors:  M Zhuo; D M Holtzman; Y Li; H Osaka; J DeMaro; M Jacquin; G Bu
Journal:  J Neurosci       Date:  2000-01-15       Impact factor: 6.167

2.  Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation.

Authors:  Angela R Jockheck-Clark; Edith V Bowers; Mariam B Totonchy; Julie Neubauer; Salvatore V Pizzo; Christopher V Nicchitta
Journal:  J Immunol       Date:  2010-11-03       Impact factor: 5.422

3.  Stressed neurons protect themselves by a tissue-type plasminogen activator-mediated EGFR-dependent mechanism.

Authors:  E Lemarchand; E Maubert; B Haelewyn; C Ali; M Rubio; D Vivien
Journal:  Cell Death Differ       Date:  2015-06-12       Impact factor: 15.828

4.  Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B.

Authors:  Donald L Gillian-Daniel; Paul W Bates; Angie Tebon; Alan D Attie
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

5.  Tissue and urokinase plasminogen activators instigate the degeneration of retinal ganglion cells in a mouse model of glaucoma.

Authors:  Shravan K Chintala
Journal:  Exp Eye Res       Date:  2015-10-22       Impact factor: 3.467

6.  The role of the LDL receptor in apolipoprotein B secretion.

Authors:  J Twisk; D L Gillian-Daniel; A Tebon; L Wang; P H Barrett; A D Attie
Journal:  J Clin Invest       Date:  2000-02       Impact factor: 14.808

7.  39-kDa receptor-associated protein (RAP) facilitates secretion and ligand binding of extracellular region of very-low-density-lipoprotein receptor: implications for a distinct pathway from low-density-lipoprotein receptor.

Authors:  A Sato; Y Shimada; J Herz; T Yamamoto; H Jingami
Journal:  Biochem J       Date:  1999-07-15       Impact factor: 3.857

Review 8.  Lysine acetylation in the lumen of the ER: a novel and essential function under the control of the UPR.

Authors:  Mariana Pehar; Luigi Puglielli
Journal:  Biochim Biophys Acta       Date:  2012-12-13

9.  Impaired thyroglobulin (Tg) secretion by FRTL-5 cells transfected with soluble receptor associated protein (RAP): evidence for a role of RAP in the Tg biosynthetic pathway.

Authors:  S Lisi; L Chiovato; A Pinchera; C Marcocci; F Menconi; E Morabito; M A Altea; R T McCluskey; M Marinò
Journal:  J Endocrinol Invest       Date:  2003-11       Impact factor: 4.256

10.  Norrin attenuates protease-mediated death of transformed retinal ganglion cells.

Authors:  Song Lin; Mei Cheng; Wendelin Dailey; Kimberly Drenser; Shravan Chintala
Journal:  Mol Vis       Date:  2009-01-12       Impact factor: 2.367
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