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Literature DB >> 971409

Toxicity of various carrageenans in the mouse.

Abstract

Carrageenan toxicity was found to vary according to the biochemical nature and source of material injected. Ischaemic lesions of body extremities (acronecrosis) were produced by some but not all preparations. Histological examination of these sites and of both recent and old organ lesions (especially of liver and kidney) confirmed that the underlying pathology was disseminated intravascular coagulation. Evidence was also obtained that carrageenans are hepatotoxic.

Entities: Chemical Disease Species

Mesh：

Substances：
Carrageenan

Year: 1976 PMID： 971409 PMCID： PMC2041165

Source DB: PubMed Journal: Br J Exp Pathol ISSN： 0007-1021

9 in total

1. Failure of carrageenan to affect graft-versus-host reactivity in the rat.

Authors: A W Thomson; C H Horne
Journal: Transplantation Date: 1975-11 Impact factor: 4.939

2. Studies on the character and staining of fibrin.

Authors: A C LENDRUM; D S FRASER; W SLIDDERS; R HENDERSON
Journal: J Clin Pathol Date: 1962-09 Impact factor: 3.411

3. Suppression of primary immunization by carrageenan - a macrophage toxic agent.

Authors: D E Bice; D G Gruwell; J E Salvaggio; E O Hoffmann
Journal: Immunol Commun Date: 1972

Review 4. Biological properties of carrageenan.

Authors: M Di Rosa
Journal: J Pharm Pharmacol Date: 1972-02 Impact factor: 3.765

5. The effect of carrageenan on the establishment of delayed hypersensitivity.

Authors: D Bice; H J Schwartz; W W Lake; J Salvaggio
Journal: Int Arch Allergy Appl Immunol Date: 1971

6. The immunodepressant effect of carrageenin.

Authors: L Aschheim; S Raffel
Journal: J Reticuloendothel Soc Date: 1972-03

7. Carrageenan and delayed hypersensitivity. II. Activation of Hageman factor by carrageenan and its possible significance.

Authors: H J Schwartz; R W Kellermeyer
Journal: Proc Soc Exp Biol Med Date: 1969-12

8. Evaluation of carrageenan as an immunosuppressive agent and mediator of intravascular coagulation.

Authors: A W Thomson; A R Wilson; W J Cruickshank; C H Horne
Journal: Biomedicine Date: 1976-05

9. Spectrum and possible mechanism of carrageenan cytotoxicity.

Authors: P J Catanzaro; H J Schwartz; R C Graham
Journal: Am J Pathol Date: 1971-08 Impact factor: 4.307

9 in total

13 in total

9. A histopathological study of the effects of intravenously administered lambda carrageenan in the mouse, with particular reference to the macrophage system.

Authors: P R Steele; J R Lowes
Journal: Br J Exp Pathol Date: 1979-08

Review 10. Carrageenan: a review of its effects on the immune system.

Authors: A W Thomson; E F Fowler
Journal: Agents Actions Date: 1981-05

Toxicity of various carrageenans in the mouse.

1. Failure of carrageenan to affect graft-versus-host reactivity in the rat.

2. Studies on the character and staining of fibrin.

3. Suppression of primary immunization by carrageenan - a macrophage toxic agent.

Review 4. Biological properties of carrageenan.

5. The effect of carrageenan on the establishment of delayed hypersensitivity.

6. The immunodepressant effect of carrageenin.

7. Carrageenan and delayed hypersensitivity. II. Activation of Hageman factor by carrageenan and its possible significance.

8. Evaluation of carrageenan as an immunosuppressive agent and mediator of intravascular coagulation.

9. Spectrum and possible mechanism of carrageenan cytotoxicity.

1. Algal toxins.

2. Serum IgG, IgM and slow alpha-globulin levels in carrageenan-treated rats.

3. A re-evaluation of the role of macrophages in carrageenan-induced immunosuppression.

4. Alleviation of carrageenan-induced hepatotoxicity and acronecrosis by aprotinin.

5. Desulfated carrageenans and cytotoxicity of human monocytes.

6. Interferon induction by the immunomodulating polyanion lambda carrageenan.

7. Haematological changes following systemic injection of purified carrageenans (kappa, lambda and iota).

8. NK activity in carrageenan-treated mice.

9. A histopathological study of the effects of intravenously administered lambda carrageenan in the mouse, with particular reference to the macrophage system.

Review 10. Carrageenan: a review of its effects on the immune system.