Literature DB >> 9714028

Pain perception following subcutaneous injections of citrate-buffered and phosphate-buffered epoetin alpha.

A W Yu1, C B Leung, P K Li, S F Lui, K N Lai.   

Abstract

Subcutaneous injection of citrate-buffered epoetin alpha (EPO-alpha) causes pain. Substitution of citrate buffer with a phosphate buffer in the EPO-alpha resulted in a significant reduction in duration and severity of pain. It is possible that sodium citrate which is present in the EPO-alpha may be the agent that causes discomfort in the patients.

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Year:  1998        PMID: 9714028

Source DB:  PubMed          Journal:  Int J Artif Organs        ISSN: 0391-3988            Impact factor:   1.595


  5 in total

1.  Subcutaneous Injection Site Pain of Formulation Matrices.

Authors:  Galen H Shi; Karthik Pisupati; Jonathan G Parker; Vincent J Corvari; Christopher D Payne; Wen Xu; David S Collins; Michael R De Felippis
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Review 2.  Differentiating factors between erythropoiesis-stimulating agents: a guide to selection for anaemia of chronic kidney disease.

Authors:  Robert Deicher; Walter H Hörl
Journal:  Drugs       Date:  2004       Impact factor: 9.546

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Authors:  Johannes M H M Reul; Florian Holsboer
Journal:  Dialogues Clin Neurosci       Date:  2002-03       Impact factor: 5.986

Review 4.  New insight into the importance of formulation variables on parenteral growth hormone preparations: potential effect on the injection-site pain.

Authors:  Bita Taghizadeh; Mahmoud Reza Jaafari; Nosratollah Zarghami
Journal:  Front Endocrinol (Lausanne)       Date:  2022-10-03       Impact factor: 6.055

5.  Highly purified human-derived follicle-stimulating hormone (Bravelle) has equivalent efficacy to follitropin-beta (Follistim) in infertile women undergoing in vitro fertilization.

Authors:  Richard P Dickey; John E Nichols; Michael P Steinkampf; Benjamin Gocial; Melvin Thornton; Bobby W Webster; Sandra M Bello; Jack Crain; Dennis C Marshall
Journal:  Reprod Biol Endocrinol       Date:  2003-10-03       Impact factor: 5.211

  5 in total

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