Literature DB >> 9713952

Achalasia in a sixty-four-year-old man.

E A Komisaruk1, N E Seymour.   

Abstract

Achalasia is an esophageal motility disorder characterized by increased lower esophageal sphincter pressure and absence of peristalsis in the lower esophagus. Patients typically present with complaints of progressive difficulty swallowing over a period of several years. Diagnosis is confirmed by esophageal manometry. Complications of achalasia include esophagitis, aspiration and possibly an increased risk of esophageal carcinoma. Medical treatment options include pneumatic dilatation, esophageal bougienage, nitrates, calcium channel blockers and botulinum toxin injections. The primary method of surgical treatment is the Heller myotomy, in which longitudinal incisions are made in the muscle fibers of the lower esophageal sphincter to reduce sphincter pressure. Frequently, a fundoplication is performed in addition to the myotomy to decrease the likelihood of development of gastroesophageal reflux. In recent years, the Heller myotomy has been performed both thoracoscopically and laparoscopically. An additional development has been the placement of an endoscope in the esophagus to provide transillumination during surgery; intraoperative endoscopy allows improved assessment of the depth of myotomy incisions and reduces the risk of esophageal perforation. The case report below describes a 64-year-old-man with achalasia who presented with persistent dysphagia despite multiple attempts at medical treatment. A laparoscopic Heller myotomy with Toupet fundoplication was performed with subsequent eradication of symptoms. A discussion of the epidemiology, etiology, clinical presentation, diagnosis and treatment of achalasia follows the case report.

Entities:  

Mesh:

Year:  1998        PMID: 9713952      PMCID: PMC2578908     

Source DB:  PubMed          Journal:  Yale J Biol Med        ISSN: 0044-0086


  22 in total

1.  An uncontrolled comparison of treatments for achalasia.

Authors:  J Yon; J Christensen
Journal:  Ann Surg       Date:  1975-12       Impact factor: 12.969

2.  A study of swallowing difficulties in first degree relatives of patients with achalasia.

Authors:  J F Mayberry; M Atkinson
Journal:  Thorax       Date:  1985-05       Impact factor: 9.139

3.  Return of peristalsis in achalasia after pneumatic dilatation.

Authors:  M Lamet; B Fleshler; E Achkar
Journal:  Am J Gastroenterol       Date:  1985-08       Impact factor: 10.864

Review 4.  Treatment of achalasia and related motor disorders.

Authors:  G Vantrappen; J Hellemans
Journal:  Gastroenterology       Date:  1980-07       Impact factor: 22.682

Review 5.  Primary oesophageal motility disorders. Current therapeutic concepts.

Authors:  M Traube; R W McCallum
Journal:  Drugs       Date:  1985-07       Impact factor: 9.546

6.  Heller myotomy via minimal-access surgery. An evaluation of antireflux procedures.

Authors:  F Raiser; G Perdikis; R A Hinder; L L Swanstrom; C J Filipi; P J McBride; N Katada; P J Neary
Journal:  Arch Surg       Date:  1996-06

7.  Integrity of cholinergic innervation to the lower esophageal sphincter in achalasia.

Authors:  R H Holloway; W J Dodds; J F Helm; W J Hogan; J Dent; R C Arndorfer
Journal:  Gastroenterology       Date:  1986-04       Impact factor: 22.682

8.  Esophageal testing of patients with noncardiac chest pain or dysphagia. Results of three years' experience with 1161 patients.

Authors:  P O Katz; C B Dalton; J E Richter; W C Wu; D O Castell
Journal:  Ann Intern Med       Date:  1987-04       Impact factor: 25.391

9.  A prospective randomized study comparing forceful dilatation and esophagomyotomy in patients with achalasia of the esophagus.

Authors:  A Csendes; N Velasco; I Braghetto; A Henriquez
Journal:  Gastroenterology       Date:  1981-04       Impact factor: 22.682

10.  Botulinum toxin for achalasia: long-term outcome and predictors of response.

Authors:  P J Pasricha; R Rai; W J Ravich; T R Hendrix; A N Kalloo
Journal:  Gastroenterology       Date:  1996-05       Impact factor: 22.682

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