Literature DB >> 971337

Microsomal mixed-function oxidases and epoxide hydratase convert benzo(a)pyrene stereospecifically to optically active dihydroxydihydrobenzo(a)pyrenes.

S K Yang, H V Gelboin.   

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Year:  1976        PMID： 971337     DOI： 10.1016/0006-2952(76)90138-6

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


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  3 in total

1.  Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

Authors:  M K Buening; P G Wislocki; W Levin; H Yagi; D R Thakker; H Akagi; M Koreeda; D M Jerina; A H Conney
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

2.  Mutagenicity and tumorigenicity of the four enantiopure bay-region 3,4-diol-1,2-epoxide isomers of dibenz[a,h]anthracene.

Authors:  Richard L Chang; Alexander W Wood; Mou Tuan Huang; Jian Guo Xie; Xiao Xing Cui; Kenneth R Reuhl; D R Boyd; Yong Lin; Weichung Joe Shih; Suresh K Balani; Haruhiko Yagi; Donald M Jerina; Allan H Conney
Journal:  Carcinogenesis       Date:  2013-05-13       Impact factor: 4.944

3.  Regio- and stereoselectivity of various forms of purified cytochrome P-450 in the metabolism of benzo[a]pyrene and (-) trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown by product formation and binding to DNA.

Authors:  J Deutsch; J C Leutz; S K Yang; H V Gelboin; Y L Chiang; K P Vatsis; M J Coon
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205
  3 in total

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