What causes Hodgkin's disease in children?

Hodgkin's disease is one of the commonest cancers of older children and adolescents, but little is known about its aetiology. Recent data, particularly in descriptive epidemiology and virology, tend to confirm the 'two-disease' hypothesis. Mixed cellularity Hodgkin's disease is more common, especially at younger ages, in poorer socioeconomic environments, whereas nodular sclerosing Hodgkin's disease has a higher incidence in more affluent societies. Approximately three-quarters of childhood Hodgkin's disease, and a higher proportion of the mixed cellularity subtype, may be a rare response to Epstein-Barr virus infection, together with an unidentified cofactor related to the degree of affluence of the population. Other infectious agents may be implicated in some cases. The already low incidence, especially of nodular sclerosis, among populations of East Asian ethnic origin and the high incidence, especially of mixed cellularity, among some populations of South Asian origin are apparently independent of socioeconomic status. This ethnic variation in risk suggests that genetic predisposition also plays a role. Detailed HLA studies may help to elucidate the complex variations between populations in the risk of Hodgkin's disease and its principal subtypes.