Literature DB >> 9712808

Protective effect of vaccination with a combination of recombinant surface antigen 1 and interleukin-12 against toxoplasmosis in mice.

V Letscher-Bru1, O Villard, B Risse, M Zauke, J P Klein, T T Kien.   

Abstract

We studied the immune response induced in mice by recombinant Toxoplasma gondii surface antigen 1 (rSAG1) protein, alone or combined with interleukin-12 (IL-12) as an adjuvant, and the protective effect against toxoplasmosis. Immunization with rSAG1 alone induced a specific humoral type 2 immunity and did not protect the animals from infection. In contrast, immunization with rSAG1 plus IL-12 redirected humoral and cellular immunity toward a type 1 pattern and reduced the brain parasite load by 40%.

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Year:  1998        PMID： 9712808      PMCID： PMC108546          DOI： 10.1128/IAI.66.9.4503-4506.1998

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  34 in total

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Authors:  F Darcy; P Maes; H Gras-Masse; C Auriault; M Bossus; D Deslee; I Godard; M F Cesbron; A Tartar; A Capron
Journal:  J Immunol       Date:  1992-12-01       Impact factor: 5.422

2.  Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.

Authors:  R T Gazzinelli; F T Hakim; S Hieny; G M Shearer; A Sher
Journal:  J Immunol       Date:  1991-01-01       Impact factor: 5.422

3.  Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii.

Authors:  J L Burg; D Perelman; L H Kasper; P L Ware; J C Boothroyd
Journal:  J Immunol       Date:  1988-11-15       Impact factor: 5.422

4.  Analysis of Toxoplasma gondii antigens recognized by human sera obtained before and after acute infection.

Authors:  I Potasman; F G Araujo; G Desmonts; J S Remington
Journal:  J Infect Dis       Date:  1986-10       Impact factor: 5.226

5.  Protection of mice from fatal Toxoplasma gondii infection by immunization with p30 antigen in liposomes.

Authors:  R Bülow; J C Boothroyd
Journal:  J Immunol       Date:  1991-11-15       Impact factor: 5.422

6.  A purified parasite antigen (p30) mediates CD8+ T cell immunity against fatal Toxoplasma gondii infection in mice.

Authors:  I A Khan; K H Ely; L H Kasper
Journal:  J Immunol       Date:  1991-11-15       Impact factor: 5.422

7.  Generation and analysis of interleukin-4 deficient mice.

Authors:  R Kühn; K Rajewsky; W Müller
Journal:  Science       Date:  1991-11-01       Impact factor: 47.728

8.  Western Blot analysis of the antigens of Toxoplasma gondii recognized by human IgM and IgG antibodies.

Authors:  S D Sharma; J Mullenax; F G Araujo; H A Erlich; J S Remington
Journal:  J Immunol       Date:  1983-08       Impact factor: 5.422

9.  IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

Authors:  F D Finkelman; I M Katona; T R Mosmann; R L Coffman
Journal:  J Immunol       Date:  1988-02-15       Impact factor: 5.422

10.  Interferon-gamma: the major mediator of resistance against Toxoplasma gondii.

Authors:  Y Suzuki; M A Orellana; R D Schreiber; J S Remington
Journal:  Science       Date:  1988-04-22       Impact factor: 47.728
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  16 in total

1.  Effect of rSAG-1(P30) immunisation on the circulating and tissue parasites in guinea pigs as determined by quantitative PCR.

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2.  Enhancement of the protective efficacy of a ROP18 vaccine against chronic toxoplasmosis by nasal route.

Authors:  Imran Rashid; Nathalie Moiré; Bruno Héraut; Isabelle Dimier-Poisson; Marie-Noëlle Mévélec
Journal:  Med Microbiol Immunol       Date:  2016-10-18       Impact factor: 3.402

3.  Vaccination with a DNA vaccine coding for perforin-like protein 1 and MIC6 induces significant protective immunity against Toxoplasma gondii.

Authors:  Hai-Kuo Yan; Zi-Guo Yuan; Hui-Qun Song; Eskild Petersen; Yang Zhou; Di Ren; Dong-Hui Zhou; Hao-Xin Li; Rui-Qing Lin; Gui-Lian Yang; Xing-Quan Zhu
Journal:  Clin Vaccine Immunol       Date:  2012-02-29

4.  Biochemical properties and vaccine effect of recombinant TPx-3 from Schistosoma japonicum.

Authors:  Yanhui Han; Bin Zhao; Min Zhang; Yang Hong; Hongxiao Han; Xiaodan Cao; Ke Lu; Jiaojiao Lin; Zhiqiang Fu
Journal:  Parasitol Res       Date:  2017-03-11       Impact factor: 2.289

5.  Cellular immune responses to recombinant antigens in pregnant women chronically infected with Toxoplasma gondii.

Authors:  A F Fatoohi; G J N Cozon; T Greenland; J Ferrandiz; J Bienvenu; S Picot; F Peyron
Journal:  Clin Diagn Lab Immunol       Date:  2002-05

6.  Recombinant GRA4 or ROP2 protein combined with alum or the gra4 gene provides partial protection in chronic murine models of toxoplasmosis.

Authors:  Valentina Martin; Alicia Supanitsky; Pablo C Echeverria; Silvana Litwin; Tamara Tanos; Adolfo R De Roodt; Eduardo A Guarnera; Sergio O Angel
Journal:  Clin Diagn Lab Immunol       Date:  2004-07

7.  Effect of codon optimization and subcellular targeting on Toxoplasma gondii antigen SAG1 expression in tobacco leaves to use in subcutaneous and oral immunization in mice.

Authors:  Melina Laguía-Becher; Valentina Martín; Mauricio Kraemer; Mariana Corigliano; María L Yacono; Alejandra Goldman; Marina Clemente
Journal:  BMC Biotechnol       Date:  2010-07-15       Impact factor: 2.563

8.  Heterogeneity in cellular and humoral immune responses against Toxoplasma gondii antigen in humans.

Authors:  A F Fatoohi; G J N Cozon; P Gonzalo; M Mayencon; T Greenland; S Picot; F Peyron
Journal:  Clin Exp Immunol       Date:  2004-06       Impact factor: 4.330

9.  Vaccination with Toxoplasma gondii SAG-1 protein is protective against congenital toxoplasmosis in BALB/c mice but not in CBA/J mice.

Authors:  Valerie Letscher-Bru; Alexander W Pfaff; Ahmed Abou-Bacar; Denis Filisetti; Elisabeth Antoni; Odile Villard; Jean-Paul Klein; Ermanno Candolfi
Journal:  Infect Immun       Date:  2003-11       Impact factor: 3.441

10.  Vaccination against murine toxoplasmosis using recombinant Toxoplasma gondii SAG3 antigen alone or in combination with Quil A.

Authors:  Young-Ha Lee; Dae-Whan Shin; Jae-Ho Lee; Ho-Woo Nam; Myoung-Hee Ahn
Journal:  Yonsei Med J       Date:  2007-06-30       Impact factor: 2.759
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