Neuropeptide Y and limbic seizures.

Since its discovery in 1982, neuropeptide Y (NPY), a 36 amino-acid member of the pancreatic polypeptide family, has received considerable attention in the field of neuroscience. Originally isolated from porcine brain /86/, NPY is one of the most abundant and widely distributed peptides in the central nervous system. In the brain, NPY is present in the hypothalamus, limbic structures, cerebral cortex, brainstem and striatum /2,71/. Because of the widespread distribution of NPY, it has been implicated in the modulation of a variety of behaviors, including, but not limited to, circadian rhythms /1/, memory retention /33/, feeding /19,56/, sympathetic control of cardiovascular function /89/ and anxiety /42,43/. These functions have been reviewed elsewhere and will not be discussed in great detail here. The present review is intended to provide an overview of recent work implicating a role for NPY in limbic seizures.