Literature DB >> 9711555

Functional assays for analysis of yeast ste6 mutants.

G L Nijbroek1, S Michaelis.   

Abstract

As a member of the ABC superfamily, STE6 is unique in that it has a well-characterized substrate, a-factor, and can be easily manipulated in the yeast system. Functional assays have been extensively used, and methods to examine trafficking and stability of STE6 are well established. In addition, STE6 chimeras and ste6 deletion strains are useful for the analysis of many nonyeast ABC proteins. Continuing studies of STE6 are expected to aid in the identification of novel cellular components involved in the trafficking and functioning of not only STE6, but of other members of the ABC superfamily as well.

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Year:  1998        PMID： 9711555     DOI： 10.1016/s0076-6879(98)92016-x

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


  13 in total

1.  Saccharomyces cerevisiae a-factor mutants reveal residues critical for processing, activity, and export.

Authors:  Gregory Huyer; Amy Kistler; Franklin J Nouvet; Carolyn M George; Meredith L Boyle; Susan Michaelis
Journal:  Eukaryot Cell       Date:  2006-09

2.  A common genetic system for functional studies of pitrilysin and related M16A proteases.

Authors:  Benjamin J Alper; Tatyana E Nienow; Walter K Schmidt
Journal:  Biochem J       Date:  2006-08-15       Impact factor: 3.857

3.  a-Factor: a chemical biology tool for the study of protein prenylation.

Authors:  Veronica Diaz-Rodriguez; Mark D Distefano
Journal:  Curr Top Pept Protein Res       Date:  2017

4.  Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues.

Authors:  Lisa J Plummer; Emily R Hildebrandt; Stephen B Porter; Victoria A Rogers; Jay McCracken; Walter K Schmidt
Journal:  J Biol Chem       Date:  2005-12-17       Impact factor: 5.157

5.  Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.

Authors:  Juan Cadiñanos; Walter K Schmidt; Antonio Fueyo; Ignacio Varela; Carlos López-Otín; José M P Freije
Journal:  Biochem J       Date:  2003-03-15       Impact factor: 3.857

Review 6.  Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.

Authors:  Susan Michaelis; Jemima Barrowman
Journal:  Microbiol Mol Biol Rev       Date:  2012-09       Impact factor: 11.056

7.  Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity.

Authors:  Jemima Barrowman; Patricia A Wiley; Sarah E Hudon-Miller; Christine A Hrycyna; Susan Michaelis
Journal:  Hum Mol Genet       Date:  2012-06-19       Impact factor: 6.150

8.  A striking quality control subcompartment in Saccharomyces cerevisiae: the endoplasmic reticulum-associated compartment.

Authors:  Gregory Huyer; Gaby L Longsworth; Deborah L Mason; Monica P Mallampalli; J Michael McCaffery; Robin L Wright; Susan Michaelis
Journal:  Mol Biol Cell       Date:  2003-12-10       Impact factor: 4.138

9.  Proteolytic processing of certain CaaX motifs can occur in the absence of the Rce1p and Ste24p CaaX proteases.

Authors:  Ranjith K Krishnankutty; Sayali S Kukday; Amanda J Castleberry; Sarah R Breevoort; Walter K Schmidt
Journal:  Yeast       Date:  2009-08       Impact factor: 3.239

10.  Topology of the yeast Ras converting enzyme as inferred from cysteine accessibility studies.

Authors:  Emily R Hildebrandt; Dillon M Davis; John Deaton; Ranjith K Krishnankutty; Edward Lilla; Walter K Schmidt
Journal:  Biochemistry       Date:  2013-09-10       Impact factor: 3.162
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