Literature DB >> 9711244

Lymphostin (LK6-A), a novel immunosuppressant from Streptomyces sp. KY11783: structural elucidation.

Y Aotani1, H Nagata, M Yoshida.   

Abstract

Lymphostin (LK6-A), a novel immunosuppressant, was isolated from the culture broth of Streptomyces sp. KY11783. Lymphostin showed potent inhibitory activity against the lymphocyte kinase, Lck (p56lck). The structure of lymphostin was determined by spectroscopic methods to be a novel tricyclic aromatic alkaloid. A key feature of the structure is the pyrrolo[4,3,2-de]quinoline moiety which is rare among natural products.

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Year:  1997        PMID： 9711244     DOI： 10.7164/antibiotics.50.543

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  13 in total

Review 1.  Genomic basis for natural product biosynthetic diversity in the actinomycetes.

Authors:  Markus Nett; Haruo Ikeda; Bradley S Moore
Journal:  Nat Prod Rep       Date:  2009-09-01       Impact factor: 13.423

2.  Marine natural products: a new wave of drugs?

Authors:  Rana Montaser; Hendrik Luesch
Journal:  Future Med Chem       Date:  2011-09       Impact factor: 3.808

3.  Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria.

Authors:  Akimasa Miyanaga; Jeffrey E Janso; Leonard McDonald; Min He; Hongbo Liu; Laurel Barbieri; Alessandra S Eustáquio; Elisha N Fielding; Guy T Carter; Paul R Jensen; Xidong Feng; Margaret Leighton; Frank E Koehn; Bradley S Moore
Journal:  J Am Chem Soc       Date:  2011-08-09       Impact factor: 15.419

Review 4.  The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery.

Authors:  Paul R Jensen; Bradley S Moore; William Fenical
Journal:  Nat Prod Rep       Date:  2015-05       Impact factor: 13.423

5.  Ammosamide D, an oxidatively ring opened ammosamide analog from a marine-derived Streptomyces variabilis.

Authors:  Ende Pan; Matthew Jamison; Muhammed Yousufuddin; John B MacMillan
Journal:  Org Lett       Date:  2012-04-20       Impact factor: 6.005

Review 6.  Applications of Friedel-Crafts reactions in total synthesis of natural products.

Authors:  Majid M Heravi; Vahideh Zadsirjan; Pegah Saedi; Tayebeh Momeni
Journal:  RSC Adv       Date:  2018-12-03       Impact factor: 4.036

7.  The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species.

Authors:  Chambers C Hughes; John B MacMillan; Susana P Gaudêncio; Paul R Jensen; William Fenical
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

8.  Precursor-Directed Generation of Amidine Containing Ammosamide Analogs: Ammosamides E-P.

Authors:  Ende Pan; Nathaniel W Oswald; Aaron G Legako; Janie M Life; Bruce A Posner; John B Macmillan
Journal:  Chem Sci       Date:  2013-01       Impact factor: 9.825

9.  Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica.

Authors:  Daniel W Udwary; Lisa Zeigler; Ratnakar N Asolkar; Vasanth Singan; Alla Lapidus; William Fenical; Paul R Jensen; Bradley S Moore
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-11       Impact factor: 11.205

10.  Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester.

Authors:  Gabriel Castro-Falcón; Grant S Seiler; Özlem Demir; Manoj K Rathinaswamy; David Hamelin; Reece M Hoffmann; Stefanie L Makowski; Anne-Catrin Letzel; Seth J Field; John E Burke; Rommie E Amaro; Chambers C Hughes
Journal:  J Med Chem       Date:  2018-11-28       Impact factor: 7.446
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