Literature DB >> 9711215

A novel bone resorption inhibitor, A-75943 isolated from Streptomyces sp. SANK 61296.

T Morishita1, A Sato, T Ando, K Oizumi, M Miyamoto, R Enokita, T Okazaki.   

Abstract

A novel bone resorption inhibitor, A-75943, was isolated from Streptomyces sp. SANK 61296. Its structure was determined to be (1"S,2'R,3"S,4S',5"S)-2-[(3",5"- dimethyl-2"-oxocyclohexan-1"-yl)-6'-oxotetrahydropyran-4'-yl ]acetamide by spectral analyses and chemical conversion of cycloheximide. A-75943 inhibited bone resorption in vitro in a concentration-dependent manner with an IC50 of 0.35 microM, and also displayed an inhibitory effect on bone resorption in thyroid and parathyroid-extracted rats.

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Year:  1998        PMID： 9711215     DOI： 10.7164/antibiotics.51.531

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

Review 1.  Nontraditional microbial bioactive metabolites.

Authors:  V Bĕhal
Journal:  Folia Microbiol (Praha)       Date:  2001       Impact factor: 2.099

2.  Comprehensive investigation of marine Actinobacteria associated with the sponge Halichondria panicea.

Authors:  Imke Schneemann; Kerstin Nagel; Inga Kajahn; Antje Labes; Jutta Wiese; Johannes F Imhoff
Journal:  Appl Environ Microbiol       Date:  2010-04-09       Impact factor: 4.792

3.  Stress-Driven Discovery of New Angucycline-Type Antibiotics from a Marine Streptomyces pratensis NA-ZhouS1.

Authors:  Najeeb Akhter; Yaqin Liu; Bibi Nazia Auckloo; Yutong Shi; Kuiwu Wang; Juanjuan Chen; Xiaodan Wu; Bin Wu
Journal:  Mar Drugs       Date:  2018-09-12       Impact factor: 5.118

4.  Production of secondary metabolites in stirred tank bioreactor co-cultures of Streptomyces noursei and Aspergillus terreus.

Authors:  Tomasz Boruta; Anna Ścigaczewska; Marcin Bizukojć
Journal:  Front Bioeng Biotechnol       Date:  2022-09-29
  4 in total

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