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Literature DB >> 9710704

Pharmacokinetics, metabolism and toxicology of dichloroacetate.

P W Stacpoole¹, G N Henderson, Z Yan, R Cornett, M O James.

Abstract

Entities: Chemical

Mesh：

Substances：
Dichloroacetic Acid

Year: 1998 PMID： 9710704 DOI： 10.3109/03602539808996323

Source DB: PubMed Journal: Drug Metab Rev ISSN： 0360-2532 Impact factor: 4.518

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34 in total

1. Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration.

Authors: Stephan C Jahn; Marci G Smeltz; Zhiwei Hu; Laura Rowland-Faux; Guo Zhong; Ryan J Lorenzo; Katherine V Cisneros; Peter W Stacpoole; Margaret O James
Journal: Biochem Pharmacol Date: 2018-04-05 Impact factor: 5.858

2. Why are there no proven therapies for genetic mitochondrial diseases?

Authors: Peter W Stacpoole
Journal: Mitochondrion Date: 2011-05-13 Impact factor: 4.160

Review 3. Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.

Authors: Margaret O James; Stephan C Jahn; Guo Zhong; Marci G Smeltz; Zhiwei Hu; Peter W Stacpoole
Journal: Pharmacol Ther Date: 2016-10-19 Impact factor: 12.310

4. DCA promotes progression of neuroblastoma tumors in nude mice.

Authors: Benedikt Feuerecker; Christof Seidl; Sabine Pirsig; Gernot Bruchelt; Reingard Senekowitsch-Schmidtke
Journal: Am J Cancer Res Date: 2015-01-15 Impact factor: 6.166

5. Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.

Authors: Naveen Mangal; Margaret O James; Peter W Stacpoole; Stephan Schmidt
Journal: J Clin Pharmacol Date: 2017-09-15 Impact factor: 3.126

6. The effect of dichloroacetate on male rat thymus and on thymocyte cell cycle.

Authors: Jurate Stanevičiūtė; Daiva Urbonienė; Angelija Valančiūtė; Ingrida Balnytė; Astra Vitkauskienė; Brigita Grigalevičienė; Donatas Stakišaitis
Journal: Int J Immunopathol Pharmacol Date: 2016-10-14 Impact factor: 3.219

7. A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors.

Authors: Quincy Siu-Chung Chu; Randeep Sangha; Jennifer Spratlin; Larissa J Vos; John R Mackey; Alexander J B McEwan; Peter Venner; Evangelos D Michelakis
Journal: Invest New Drugs Date: 2015-03-13 Impact factor: 3.850