Literature DB >> 9708544

Distinct pH homeostatic features in lymphoblasts from Alzheimer's disease patients.

D Ibarreta1, E Urcelay, R Parrilla, M S Ayuso.   

Abstract

Epstein-Barr-transformed lymphocytes from Alzheimer's disease patients showed the following distinct features in controlling the intracellular pH compared with cells from normal age-matched controls: (1) The alphaIgM-induced intracellular acidification was more pronounced in Alzheimer's disease than control cells and this effect appears to be associated with a loss of effectiveness of a Ca2+/calmodulin-dependent mechanism in controlling the activity of the Na+/H+ exchanger; and (2) the intracellular H+-buffering capacity and the rate of proton efflux in response to an acid load were both decreased in Alzheimer's disease cells. It is concluded that the amplitude of the intracellular pH changes under acid-loading conditions will always be greater in Alzheimer's disease than in control cells.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9708544     DOI： 10.1002/ana.410440212

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  12 in total

Review 1.  Oxidative stress, perturbed calcium homeostasis, and immune dysfunction in Alzheimer's disease.

Authors:  Mark P Mattson
Journal:  J Neurovirol       Date:  2002-12       Impact factor: 2.643

2.  Simvastatin overcomes the resistance to serum withdrawal-induced apoptosis of lymphocytes from Alzheimer's disease patients.

Authors:  Fernando Bartolomé; Ursula Muñoz; Noemí Esteras; Carolina Alquezar; Andrea Collado; Félix Bermejo-Pareja; Angeles Martín-Requero
Journal:  Cell Mol Life Sci       Date:  2010-07-08       Impact factor: 9.261

3.  G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients.

Authors:  Noemí Esteras; Carolina Alquézar; Fernando Bartolomé; Ana de la Encarnación; Félix Bermejo-Pareja; José Antonio Molina; Ángeles Martín-Requero
Journal:  Mol Neurobiol       Date:  2014-09-03       Impact factor: 5.590

4.  Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers.

Authors:  Carolina Alquézar; Ana de la Encarnación; Fermín Moreno; Adolfo López de Munain; Ángeles Martín-Requero
Journal:  J Psychiatry Neurosci       Date:  2016-06       Impact factor: 6.186

Review 5.  Chipping away at diagnostics for neurodegenerative diseases.

Authors:  Clemens R Scherzer
Journal:  Neurobiol Dis       Date:  2009-03-10       Impact factor: 5.996

Review 6.  Glial Na(+) -dependent ion transporters in pathophysiological conditions.

Authors:  Francesca Boscia; Gulnaz Begum; Giuseppe Pignataro; Rossana Sirabella; Ornella Cuomo; Antonella Casamassa; Dandan Sun; Lucio Annunziato
Journal:  Glia       Date:  2016-07-26       Impact factor: 7.452

7.  Distinct regulation of cell cycle and survival in lymphocytes from patients with Alzheimer's disease and amyotrophic lateral sclerosis.

Authors:  Fernando Bartolomé; Ursula Muñoz; Noemí Esteras; Jesús Esteban; Félix Bermejo-Pareja; Angeles Martín-Requero
Journal:  Int J Clin Exp Pathol       Date:  2008-12-01

8.  Inactivation of CDK/pRb pathway normalizes survival pattern of lymphoblasts expressing the FTLD-progranulin mutation c.709-1G>A.

Authors:  Carolina Alquezar; Noemí Esteras; Ainhoa Alzualde; Fermín Moreno; Matilde S Ayuso; Adolfo López de Munain; Ángeles Martín-Requero
Journal:  PLoS One       Date:  2012-05-18       Impact factor: 3.240

9.  Calmodulin levels in blood cells as a potential biomarker of Alzheimer's disease.

Authors:  Noemí Esteras; Carolina Alquézar; Ana de la Encarnación; Alberto Villarejo; Félix Bermejo-Pareja; Angeles Martín-Requero
Journal:  Alzheimers Res Ther       Date:  2013-11-07       Impact factor: 6.982

Review 10.  Role of antioxidants and a nutrient rich diet in Alzheimer's disease.

Authors:  Gerald Veurink; George Perry; Sandeep Kumar Singh
Journal:  Open Biol       Date:  2020-06-17       Impact factor: 6.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.