Literature DB >> 9708331

Synthesis and anti-HIV properties of 1,2,4,6-thiatriazin-3-one 1,1-dioxide nucleosides.

C Ochoa1, R Provencio, M L Jimeno, J Balzarini, E De Clercq.   

Abstract

Synthesis of 1,2,4,6-thiatriazine 1,1-dioxide nucleosides is now reported for the first time. In order to know the conformation of the nucleosides, a NMR study has been carried out. Anti-HIV-1 and HIV-2 properties of the nucleosides have been tested. These compounds have not shown activity at subtoxic concentrations.

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Year:  1998        PMID: 9708331     DOI: 10.1080/07328319808003462

Source DB:  PubMed          Journal:  Nucleosides Nucleotides        ISSN: 0732-8311


  1 in total

1.  Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.

Authors:  Rafał Gawin; Erik De Clercq; Lieve Naesens; Mariola Koszytkowska-Stawińska
Journal:  Bioorg Med Chem       Date:  2008-08-26       Impact factor: 3.641

  1 in total

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