AIMS: To investigate the localisation of Helicobacter pylori antigens and the expression of human heat shock proteins (HSP) in stomachs affected by MALT lymphoma. METHODS: Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylori rabbit antibodies (ORP-1 and ORP-2) and anti-human HSP60 mouse monoclonal antibodies (mAb) (LK-1 and LK-2). RESULTS: Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-human HSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted. CONCLUSIONS: Human HSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.
AIMS: To investigate the localisation of Helicobacter pylori antigens and the expression of humanheat shock proteins (HSP) in stomachs affected by MALT lymphoma. METHODS: Surgically resected stomachs from 24 patients with MALT lymphoma were immunostained with anti-H pylorirabbit antibodies (ORP-1 and ORP-2) and anti-humanHSP60mouse monoclonal antibodies (mAb) (LK-1 and LK-2). RESULTS: Follicular dendritic cells of germinal centres in the stomachs affected by MALT lymphoma were immunostained with anti-H pylori polyclonal antibodies and with anti-humanHSP60 mAb, as were the epithelial cells. None of the lymph node samples reacted. CONCLUSIONS:HumanHSP60, which cross reacts with anti-H pylori polyclonal antibodies, is often expressed on follicular dendritic cells in gastric MALT lymphoma tissues and may be aetiologically relevant to lymphomagenesis of MALT lymphoma.
Authors: R Negrini; A Savio; C Poiesi; B J Appelmelk; F Buffoli; A Paterlini; P Cesari; M Graffeo; D Vaira; G Franzin Journal: Gastroenterology Date: 1996-09 Impact factor: 22.682
Authors: E Ishii; K Yokota; T Sugiyama; Y Fujinaga; K Ayada; I Hokari; S Hayashi; Y Hirai; M Asaka; K Oguma Journal: Clin Diagn Lab Immunol Date: 2001-11
Authors: Y Kawahara; K Yokota; M Mizuno; N Yunoki; T Uesu; H Okada; K Kobayashi; Y Hirai; K Oguma; T Tsuji Journal: Gut Date: 1999-07 Impact factor: 23.059
Authors: N Yunoki; K Yokota; M Mizuno; Y Kawahara; M Adachi; H Okada; S Hayashi; Y Hirai; K Oguma; T Tsuji Journal: Clin Diagn Lab Immunol Date: 2000-07
Authors: Harald Seeberger; Constanze Knörr; Christian Mainhardt; Hans Konrad Müller-Hermelink; Axel Greiner Journal: Virchows Arch Date: 2003-02-19 Impact factor: 4.064