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Literature DB >> 9707615

ATM binds to beta-adaptin in cytoplasmic vesicles.

D S Lim¹, D G Kirsch, C E Canman, J H Ahn, Y Ziv, L S Newman, R B Darnell, Y Shiloh, M B Kastan.

Abstract

Inherited mutations in the ATM gene lead to a complex clinical phenotype characterized by neuronal degeneration, oculocutaneous telangiectasias, immune dysfunction, and cancer predisposition. Using the yeast two-hybrid system, we demonstrate that ataxia telangiectasia mutated (ATM) binds to beta-adaptin, one of the components of the AP-2 adaptor complex, which is involved in clathrin-mediated endocytosis of receptors. The interaction between ATM and beta-adaptin was confirmed in vitro, and coimmunoprecipitation and colocalization studies show that the proteins also associate in vivo. ATM also interacts in vitro with beta-NAP, a neuronal-specific beta-adaptin homolog that was identified as an autoantigen in a patient with cerebellar degeneration. Our data describing the association of ATM with beta-adaptin in vesicles indicate that ATM may play a role in intracellular vesicle and/or protein transport mechanisms.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1998 PMID： 9707615 PMCID： PMC21476 DOI： 10.1073/pnas.95.17.10146

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

46 in total

1. A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein beta-adaptin.

Authors: T Serafini; G Stenbeck; A Brecht; F Lottspeich; L Orci; J E Rothman; F T Wieland
Journal: Nature Date: 1991-01-17 Impact factor: 49.962

Review 2. The role of clathrin, adaptors and dynamin in endocytosis.

Authors: M S Robinson
Journal: Curr Opin Cell Biol Date: 1994-08 Impact factor: 8.382

3. Role of Drosophila alpha-adaptin in presynaptic vesicle recycling.

Authors: M González-Gaitán; H Jäckle
Journal: Cell Date: 1997-03-21 Impact factor: 41.582

4. The appendage domain of alpha-adaptin is a high affinity binding site for dynamin.

Authors: L H Wang; T C Südhof; R G Anderson
Journal: J Biol Chem Date: 1995-04-28 Impact factor: 5.157

5. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.

Authors: K K Khanna; M F Lavin
Journal: Oncogene Date: 1993-12 Impact factor: 9.867

6. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

Authors: T Durfee; K Becherer; P L Chen; S H Yeh; Y Yang; A E Kilburn; W H Lee; S J Elledge
Journal: Genes Dev Date: 1993-04 Impact factor: 11.361

7. Interaction of phosphoinositide cycle intermediates with the plasma membrane-associated clathrin assembly protein AP-2.

Authors: K A Beck; J H Keen
Journal: J Biol Chem Date: 1991-03-05 Impact factor: 5.157

8. Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2.

Authors: S M Voglmaier; J H Keen; J E Murphy; C D Ferris; G D Prestwich; S H Snyder; A B Theibert
Journal: Biochem Biophys Res Commun Date: 1992-08-31 Impact factor: 3.575

9. The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.

Authors: C E Canman; A C Wolff; C Y Chen; A J Fornace; M B Kastan
Journal: Cancer Res Date: 1994-10-01 Impact factor: 12.701

10. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.

Authors: M B Kastan; Q Zhan; W S el-Deiry; F Carrier; T Jacks; W V Walsh; B S Plunkett; B Vogelstein; A J Fornace
Journal: Cell Date: 1992-11-13 Impact factor: 41.582

62 in total

1. Mitochondrial dysfunction in ataxia-telangiectasia.

Authors: Yasmine A Valentin-Vega; Kirsteen H Maclean; Jacqueline Tait-Mulder; Sandra Milasta; Meredith Steeves; Frank C Dorsey; John L Cleveland; Douglas R Green; Michael B Kastan
Journal: Blood Date: 2011-12-05 Impact factor: 22.113

2. ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation.

Authors: C Barlow; C Ribaut-Barassin; T A Zwingman; A J Pope; K D Brown; J W Owens; D Larson; E A Harrington; A M Haeberle; J Mariani; M Eckhaus; K Herrup; Y Bailly; A Wynshaw-Boris
Journal: Proc Natl Acad Sci U S A Date: 2000-01-18 Impact factor: 11.205

ATM binds to beta-adaptin in cytoplasmic vesicles.

1. A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein beta-adaptin.

Review 2. The role of clathrin, adaptors and dynamin in endocytosis.

3. Role of Drosophila alpha-adaptin in presynaptic vesicle recycling.

4. The appendage domain of alpha-adaptin is a high affinity binding site for dynamin.

5. Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.

6. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

7. Interaction of phosphoinositide cycle intermediates with the plasma membrane-associated clathrin assembly protein AP-2.

8. Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2.

9. The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.

10. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.

1. Mitochondrial dysfunction in ataxia-telangiectasia.

2. ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation.

3. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system.

4. Differential localization of ATM is correlated with activation of distinct downstream signaling pathways.

5. Mantle cell lymphoma is characterized by inactivation of the ATM gene.

6. Regulation of hyphal morphogenesis and the DNA damage response by the Aspergillus nidulans ATM homolog AtmA.

7. Regulation of protein synthesis by ionizing radiation.

8. Cytoplasmic ATM in neurons modulates synaptic function.

Review 9. Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions.

10. Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death.