H Slyter1. 1. The Permanente Medical Group, Kaiser Foundation Hospital, Sacramento, Calif 95825, USA. Howard.Slyter@NCAL.KAIPERM.ORG
Abstract
BACKGROUND: Ethical issues are a critical consideration in the design and conduct of clinical research. SUMMARY OF REVIEW: A number of completed trials of proposed stroke treatments raise classical ethical issues in challenging ways. The combination of acutely ill and vulnerable patients, the use of potentially toxic drugs, and very short time frames for decision making and drug administration demand an especially careful evaluation of risk and benefit, the process of consent, and the permissible treatment of control patients. CONCLUSIONS: The study of acute stroke treatments may require more complex safeguards than other neuroclinical trials.
BACKGROUND: Ethical issues are a critical consideration in the design and conduct of clinical research. SUMMARY OF REVIEW: A number of completed trials of proposed stroke treatments raise classical ethical issues in challenging ways. The combination of acutely ill and vulnerable patients, the use of potentially toxic drugs, and very short time frames for decision making and drug administration demand an especially careful evaluation of risk and benefit, the process of consent, and the permissible treatment of control patients. CONCLUSIONS: The study of acute stroke treatments may require more complex safeguards than other neuroclinical trials.
Authors: Daniel S Chow; Jason S Hauptman; Tony T Wong; Nestor R Gonzalez; Neil A Martin; Angella A Lignelli; Michael W Itagaki Journal: Surg Neurol Int Date: 2012-02-15
Authors: Götz Thomalla; Florent Boutitie; Jochen B Fiebach; Claus Z Simonsen; Norbert Nighoghossian; Salvador Pedraza; Robin Lemmens; Pascal Roy; Keith W Muir; Christoph Heesen; Martin Ebinger; Ian Ford; Bastian Cheng; Tae-Hee Cho; Josep Puig; Vincent Thijs; Matthias Endres; Jens Fiehler; Christian Gerloff Journal: Neurology Date: 2017-08-25 Impact factor: 9.910