Literature DB >> 9707013

Hypertrophic cardiomyopathy with type I CD36 deficiency.

K Watanabe1, K Toba, Y Ogawa, M Kodama, S Hirono, Y Ohkura, H Hanawa, Y Nakamura, Y Aoki, I Fuse, Y Aizawa, S Miyajima, Y Kusano, T Nagatomo, G Hasegawa, M Naito.   

Abstract

CD36 is a multifunctional membrane-type receptor glycoprotein that reacts with oxidized low-density lipoprotein and long-chain fatty acid (LCFA). A patient presented with hereditary hypertrophic cardiomyopathy (HCM) and type I CD36 deficiency (neither platelets nor monocytes expressed CD36) but showed no myocardial LCFA accumulation. CD36 was expressed in the capillary endothelial cells of the cardiac muscle of a control subject, while the patient's myocardial capillary endothelial cells were completely CD36-negative. These results suggest that type I CD36 deficiency is closely related to hereditary HCM and lack of myocardial LCFA accumulation.

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Year:  1998        PMID： 9707013     DOI： 10.1253/jcj.62.541

Source DB:  PubMed          Journal:  Jpn Circ J        ISSN： 0047-1828


  6 in total

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Authors:  M Febbraio; E Guy; C Coburn; F F Knapp; A L Beets; N A Abumrad; R L Silverstein
Journal:  Mol Cell Biochem       Date:  2002-10       Impact factor: 3.396

Review 2.  Metabolic cardiomyopathies.

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3.  Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart.

Authors:  Jingying Wang; Heng Ma; Chao Tong; Hanying Zhang; Gavin B Lawlis; Yuanda Li; Mengwei Zang; Jun Ren; Mark J Nijland; Stephen P Ford; Peter W Nathanielsz; Ji Li
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Review 4.  Endothelial fatty acid transport: role of vascular endothelial growth factor B.

Authors:  Carolina Hagberg; Annika Mehlem; Annelie Falkevall; Lars Muhl; Ulf Eriksson
Journal:  Physiology (Bethesda)       Date:  2013-03

5.  Common variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass.

Authors:  Darroch Hall; Bongani M Mayosi; Thahira J Rahman; Peter J Avery; Hugh C Watkins; Bernard Keavney
Journal:  J Hypertens       Date:  2011-04       Impact factor: 4.844

6.  CD36 mRNA and Protein Expression Levels Are Significantly Increased in the Heart and Testis of apoE Deficient Mice in Comparison to Wild Type (C57BL/6).

Authors:  Kazem Zibara; Eric Malaud; John L. McGregor
Journal:  J Biomed Biotechnol       Date:  2002
  6 in total

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