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Literature DB >> 9705610

IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release.

Abstract

The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.

Entities: Chemical Gene

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Year: 1998 PMID： 9705610 PMCID： PMC1781850 DOI： 10.1080/09629359891162

Source DB: PubMed Journal: Mediators Inflamm ISSN： 0962-9351 Impact factor: 4.711

25 in total

1. Antibody and inhibitor of chymase inhibit histamine release in immunoglobulin E-activated mast cells.

Authors: H Kido; N Fukusen; N Katunuma
Journal: Biochem Int Date: 1985-06

2. The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red Sea turtle proteinase inhibitor.

Authors: U Seemüller; M Arnhold; H Fritz; K Wiedenmann; W Machleidt; R Heinzel; H Appelhans; H G Gassen; F Lottspeich
Journal: FEBS Lett Date: 1986-04-07 Impact factor: 4.124

IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release.

1. Antibody and inhibitor of chymase inhibit histamine release in immunoglobulin E-activated mast cells.

2. The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red Sea turtle proteinase inhibitor.

3. [On a hormone dependent inhibitor of proteolytic enzymes in male accessory sex glands and in sperm].

Review 4. Mediators of immediate hypersensitivity.

5. Properties of protease in mast cell granules.

6. Activation of rat serosal mast cells by chymase, an endogenous secretory granule protease.

7. Granulocyte collagenase, elastase and plasma protease inhibitors in purulent sputum.

8. Inhibition of elastase from granulocytes by the low molecular weight bronchial protease inhibitor.

9. Effect of human leukocyte enzymes on tracheal mucosa and its mucociliary activity.

10. Characteristics of histamine release from cultured human mast cells.

1. Secretory leukocyte protease inhibitor plays an important role in the regulation of allergic asthma in mice.

2. Human mast cells decrease SLPI levels in type II - like alveolar cell model, in vitro.