Literature DB >> 9705582

Gene-environment interaction in Alzheimer's disease: a potential role for cholesterol.

V Chandra1, R Pandav.   

Abstract

Alzheimer's disease is probably a complex disease caused by an interaction of multiple environmental and genetic factors. Genetic defects include 'causative' genes which are rare and a 'susceptibility' gene (sigma4 allele of apolipoprotein E) which is more common in cases. Recent research suggests that environmental factors may interact with a genetic predisposition to modify the risk of Alzheimer's disease. An interaction between serum cholesterol levels and sigma4 genotype is proposed. The evidence for this gene-environment interaction is discussed.

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Year:  1998        PMID： 9705582     DOI： 10.1159/000026175

Source DB:  PubMed          Journal:  Neuroepidemiology        ISSN： 0251-5350            Impact factor:   3.282


  14 in total

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