| Literature DB >> 970489 |
R H Gerner, R M Post, W E Bunney.
Abstract
The authors present a case study that explores the relationship of dopamine function and manic illness through the use of two drugs with relatively specific effects in stimulating and blocking dopamine receptors--piribedil (ET--495) and pimozide, respectively. Piribedil, as well as d-amphetamine, was associated with manic episodes, while pimozide had an antimanic effect. These observations suggest that dopaminergic mechanisms may be involved in the mediation of manic episodes in at least some patients.Entities:
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Year: 1976 PMID： 970489 DOI： 10.1176/ajp.133.10.1177
Source DB: PubMed Journal: Am J Psychiatry ISSN： 0002-953X Impact factor: 18.112