Literature DB >> 9704880

RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter.

S I Dworkin1, P Lambert, G M Sizemore, F I Carroll, M J Kuhar.   

Abstract

RTI-113 [3beta-(4-chlorophenyl)tropan-2beta carboxylic acid phenyl ester hydrochloride], one of many phenyltropanes potent at and selective for DAT, inhibited self-administration of cocaine in rat at doses that did not alter responding maintained by food. The doses that inhibited cocaine intake produced significant levels of occupancy of DAT.

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Year:  1998        PMID： 9704880     DOI： 10.1002/(SICI)1098-2396(199809)30:1<49::AID-SYN6>3.0.CO;2-K

Source DB:  PubMed          Journal:  Synapse        ISSN： 0887-4476            Impact factor:   2.562


  8 in total

1.  Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine.

Authors:  Jeffrey S Stehouwer; Mark M Goodman
Journal:  PET Clin       Date:  2009-01

2.  Cocaine withdrawal alters the reward omission effect and enhances traits of negative urgency in rats across multiple days of testing.

Authors:  Alan T Barker; G V Rebec
Journal:  Drug Alcohol Depend       Date:  2016-06-01       Impact factor: 4.492

3.  Effect of HD-23, a potent long acting cocaine-analog, on cocaine self-administration in rats.

Authors:  David C S Roberts; Kelly R Jungersmith; Rachel Phelan; Timothy M Gregg; Huw M L Davies
Journal:  Psychopharmacology (Berl)       Date:  2003-04-01       Impact factor: 4.530

4.  Effects of the dopamine reuptake inhibitor PTT on reinstatement and on food- and cocaine-maintained responding in rhesus monkeys.

Authors:  Joshua A Lile; Drake Morgan; Anne M Birmingham; Huw M L Davies; Michael A Nader
Journal:  Psychopharmacology (Berl)       Date:  2004-07       Impact factor: 4.530

Review 5.  Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction.

Authors:  Richard B Rothman; Michael H Baumann; Thomas E Prisinzano; Amy Hauck Newman
Journal:  Biochem Pharmacol       Date:  2007-08-09       Impact factor: 5.858

Review 6.  Agents in development for the management of cocaine abuse.

Authors:  David A Gorelick; Eliot L Gardner; Zheng-Xiong Xi
Journal:  Drugs       Date:  2004       Impact factor: 9.546

7.  Assessment of reinforcing effects of benztropine analogs and their effects on cocaine self-administration in rats: comparisons with monoamine uptake inhibitors.

Authors:  Takato Hiranita; Paul L Soto; Amy H Newman; Jonathan L Katz
Journal:  J Pharmacol Exp Ther       Date:  2009-02-19       Impact factor: 4.030

8.  Effects of the monoamine uptake inhibitors RTI-112 and RTI-113 on cocaine- and food-maintained responding in rhesus monkeys.

Authors:  S S Negus; N K Mello; H L Kimmel; L L Howell; F I Carroll
Journal:  Pharmacol Biochem Behav       Date:  2008-08-08       Impact factor: 3.533
  8 in total

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