Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 SPARC/osteonectin mRNA is induced in blood vessels following injury to the adult rat cerebral cortex.

Literature DB >> 9704602

SPARC/osteonectin mRNA is induced in blood vessels following injury to the adult rat cerebral cortex.

Abstract

Recently we described the pattern of expression of the anti-adhesive glycoprotein SPARC/osteonectin in the developing and adult brain. SPARC mRNA was present in developing blood vessels during neurogenesis, but was not detected in the mature vasculature. We have now examined the effect of a lesion to the adult rat cerebral cortex on the expression of SPARC by in situ hybridization. SPARC mRNA was increased in the zone proximal to the wound at 3 to 10 days after cortical brain injury. During this period, SPARC was induced in mature blood vessels close to the lesion site and in blood vessels which develop following injury. These results suggest a role for SPARC in the process of angiogenesis following injury to the adult cerebral cortex.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1998 PMID： 9704602 DOI： 10.1023/a:1020720405428

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

35 in total

Review 1. Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin.

Authors: E H Sage; P Bornstein
Journal: J Biol Chem Date: 1991-08-15 Impact factor: 5.157

Review 2. Functional plasticity of microglia: a review.

Authors: W J Streit; M B Graeber; G W Kreutzberg
Journal: Glia Date: 1988 Impact factor: 7.452

3. SC1, a brain extracellular matrix glycoprotein related to SPARC and follistatin, is expressed by rat cerebellar astrocytes following injury and during development.

Authors: D B Mendis; G O Ivy; I R Brown
Journal: Brain Res Date: 1996-08-19 Impact factor: 3.252

4. Expression of the gene encoding the extracellular matrix glycoprotein SPARC in the developing and adult mouse brain.

Authors: D B Mendis; I R Brown
Journal: Brain Res Mol Brain Res Date: 1994-07

5. Immunohistochemical studies on the proliferation of reactive astrocytes and the expression of cytoskeletal proteins following brain injury in rats.

Authors: Y Takamiya; S Kohsaka; S Toya; M Otani; Y Tsukada
Journal: Brain Res Date: 1988-02-01 Impact factor: 3.252

6. Characterization of a novel serum albumin-binding glycoprotein secreted by endothelial cells in culture.

Authors: H Sage; C Johnson; P Bornstein
Journal: J Biol Chem Date: 1984-03-25 Impact factor: 5.157

7. The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors.

Authors: E W Raines; T F Lane; M L Iruela-Arispe; R Ross; E H Sage
Journal: Proc Natl Acad Sci U S A Date: 1992-02-15 Impact factor: 11.205

8. Trauma-induced proliferation of astrocytes in the brains of young and aged rats.

Authors: K S Topp; B T Faddis; V K Vijayan
Journal: Glia Date: 1989 Impact factor: 7.452

9. Functional mapping of SPARC: peptides from two distinct Ca+(+)-binding sites modulate cell shape.

Authors: T F Lane; E H Sage
Journal: J Cell Biol Date: 1990-12 Impact factor: 10.539

10. Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11.

Authors: I J Mason; D Murphy; M Münke; U Francke; R W Elliott; B L Hogan
Journal: EMBO J Date: 1986-08 Impact factor: 11.598

14 in total

1. Induction of SC1 mRNA encoding a brain extracellular matrix glycoprotein related to SPARC following lesioning of the adult rat forebrain.

Authors: D B Mendis; G O Ivy; I R Brown
Journal: Neurochem Res Date: 2000-12 Impact factor: 3.996

2. Expression of SPARC (secreted protein, acidic and rich in cysteine) in healing intestinal anastomoses and short bowel syndrome in rats.

Authors: P Puolakkainen; M Reed; P Vento; E H Sage; T Kiviluoto; E Kivilaakso
Journal: Dig Dis Sci Date: 1999-08 Impact factor: 3.199

3. Preventing effects of joint contracture by high molecular weight hyaluronan injections in a rat immobilized knee model.

Authors: Kenji Kanazawa; Yoshihiro Hagiwara; Masahiro Tsuchiya; Yutaka Yabe; Kazuaki Sonofuchi; Masashi Koide; Takuya Sekiguchi; Nobuyuki Itaya; Akira Ando; Yoshifumi Saijo; Eiji Itoi
Journal: Int J Clin Exp Pathol Date: 2015-04-01

4. Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma.

Authors: Shanna A Arnold; Lee B Rivera; Andrew F Miller; Juliet G Carbon; Sean P Dineen; Yang Xie; Diego H Castrillon; E Helene Sage; Pauli Puolakkainen; Amy D Bradshaw; Rolf A Brekken
Journal: Dis Model Mech Date: 2009-12-09 Impact factor: 5.758

5. Proteomic Characterization of Cerebrospinal Fluid from Ataxia-Telangiectasia (A-T) Patients Using a LC/MS-Based Label-Free Protein Quantification Technology.

Authors: Monika Dzieciatkowska; Guihong Qi; Jinsam You; Kerry G Bemis; Heather Sahm; Howard M Lederman; Thomas O Crawford; Lawrence M Gelbert; Cynthia Rothblum-Oviatt; Mu Wang
Journal: Int J Proteomics Date: 2011-06-23

6. Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFβ activation.

Authors: Shanna A Arnold; Lee B Rivera; Juliet G Carbon; Jason E Toombs; Chi-Lun Chang; Amy D Bradshaw; Rolf A Brekken
Journal: PLoS One Date: 2012-02-14 Impact factor: 3.240

7. SPARC expression by cerebral microvascular endothelial cells in vitro and its influence on blood-brain barrier properties.

Authors: Samir Alkabie; Jayasree Basivireddy; Lixin Zhou; Jane Roskams; Peter Rieckmann; Jacqueline A Quandt
Journal: J Neuroinflammation Date: 2016-08-31 Impact factor: 8.322