Literature DB >> 9704405

Nef--an adaptor adaptor?

J Oldridge1, M Marsh.   

Abstract

The Nef protein of human immunodeficiency virus (HIV) is a crucial factor in viral pathogenesis. One of the roles of this multifunctional protein is to decrease the cell-surface expression of CD4, a component of the virus receptor complex, and of MHC class I molecules. New results indicate that Nef can link CD4 to endocytic clathrin adaptor complexes and might also modulate other steps in the endocytic pathway.

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Year:  1998        PMID： 9704405     DOI： 10.1016/s0962-8924(98)01318-x

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  16 in total

1.  Mechanism for down-regulation of CD28 by Nef.

Authors:  T Swigut; N Shohdy; J Skowronski
Journal:  EMBO J       Date:  2001-04-02       Impact factor: 11.598

Review 2.  Regulation of neuronal function by protein trafficking: a role for the endosomal pathway.

Authors:  K M Buckley; H E Melikian; C J Provoda; M T Waring
Journal:  J Physiol       Date:  2000-05-15       Impact factor: 5.182

3.  Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions.

Authors:  E Schaeffer; R Geleziunas; W C Greene
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

4.  Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.

Authors:  S Le Gall; F Buseyne; A Trocha; B D Walker; J M Heard; O Schwartz
Journal:  J Virol       Date:  2000-10       Impact factor: 5.103

5.  Myristoyl moiety of HIV Nef is involved in regulation of the interaction with calmodulin in vivo.

Authors:  Mamoru Matsubara; Tao Jing; Kumi Kawamura; Naoshi Shimojo; Koiti Titani; Keiichiro Hashimoto; Nobuhiro Hayashi
Journal:  Protein Sci       Date:  2005-01-04       Impact factor: 6.725

6.  Restoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.

Authors:  M Khan; M Garcia-Barrio; M D Powell
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

7.  An endocytic YXXΦ (YRRF) cargo sorting motif in the cytoplasmic tail of murine cytomegalovirus AP2 'adapter adapter' protein m04/gp34 antagonizes virus evasion of natural killer cells.

Authors:  Annette Fink; Franziska Blaum; Marina Babic Cac; Stefan Ebert; Niels A W Lemmermann; Matthias J Reddehase
Journal:  Med Microbiol Immunol       Date:  2015-04-08       Impact factor: 3.402

8.  Physical association of the K3 protein of gamma-2 herpesvirus 68 with major histocompatibility complex class I molecules with impaired peptide and beta(2)-microglobulin assembly.

Authors:  Y Y Lawrence Yu; Michael R Harris; Lonnie Lybarger; Lisa A Kimpler; Nancy B Myers; Herbert W Virgin; Ted H Hansen
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

9.  CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression.

Authors:  Nicoletta Casartelli; Gigliola Di Matteo; Marina Potestà; Paolo Rossi; Margherita Doria
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

10.  A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.

Authors:  Rittik Chaudhuri; Rafael Mattera; O Wolf Lindwasser; Margaret S Robinson; Juan S Bonifacino
Journal:  J Virol       Date:  2009-01-07       Impact factor: 5.103
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