Evidence of differential mycobacterial growth and modulation of mycobactericidal property by glucoaminylmuramyl dipeptide in murine macrophages.

These results show that given a source of mouse tissue macrophage, there is differential mycobacterial growth with different species of mycobacteria. This suggests that each species of mycobacteria generates a differential response in a given tissue macrophage within the same host for its survival. For example, BCG-P growth becomes permissive in the presence of GMDP in splenic and peritoneal macrophages. Whereas in the same tissue M. tuberculosis growth becomes non-permissive. From Table 2 it is evident that inhibition of inflammatory responses following M. tuberculosis infection leads to reduction of viable organisms in murine macrophages.