| Literature DB >> 9701730 |
P D Rye1, N V Bovin, E V Vlasova, A A Molodyk, A Baryshnikov, F T Kreutz, W I Garinther, B C Schultes, A A Noujaim, R Madiyalakan, J Magnani, O Nilsson, K Nilsson, K Nustad, L Norum, H Bell, Y Cao, M R Suresh, D L Very, J V Freeman, K K Yeung, J Hilgers.
Abstract
The ISOBM TD-6 Workshop is the first international workshop on monoclonal antibodies against the Sialyl Lewisa (SLea) antigen. Eight research groups participated in a blind study to characterize the epitope binding, relative affinity and performance in immunoradiometric assays, of a panel of 20 monoclonal antibodies. The antibodies were tested against a diverse panel of neoglycoconjugates, purified antigens and human serum pools from gastrointestinal malignancies. Epitope specificities were determined for the majority of antibodies in the panel. Cross-reactivity with related saccharide structures was noted in several antibodies. Overall, the results of the TD-6 Workshop show further development of SLea immunoassays may yield yet more specific assays for the detection and management of gastrointestinal and other malignancies.Entities:
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Year: 1998 PMID： 9701730 DOI： 10.1159/000030032
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283