Literature DB >> 9701050

Nitric oxide: cytotoxicity versus cytoprotection--how, why, when, and where?

K D Kröncke1, K Fehsel, V Kolb-Bachofen.   

Abstract

Nitric oxide (NO) has been found to play an important role as a signal molecule in many parts of the organism as well as a cytotoxic effector molecule of the nonspecific immune response. It appears paradoxical that NO on one side acts as a physiological intercellular messenger and on the other side may display cytotoxic activity in vivo. To make things even more complicated, cytoprotective properties of NO are also described. We here review the current understanding of cytotoxic versus cytoprotective effects of NO in mammalian cells and try to highlight the janus-faced properties of this important small molecule.

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Year:  1997        PMID： 9701050     DOI： 10.1006/niox.1997.0118

Source DB:  PubMed          Journal:  Nitric Oxide        ISSN： 1089-8603            Impact factor:   4.427


  73 in total

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9.  Nitric Oxide Modulates Endonuclease III Redox Activity by a 800 mV Negative Shift upon [Fe4S4] Cluster Nitrosylation.

Authors:  Levi A Ekanger; Paul H Oyala; Annie Moradian; Michael J Sweredoski; Jacqueline K Barton
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