Literature DB >> 9700935

Syntheses and calcium channel antagonist activity of nifedipine analogues with methylsulfonylimidazolyl substituent.

A Shafiee1, A R Dehpour, F Hadizadeh, M Azimi.   

Abstract

Various diester analogues of nifedipine in which the ortho nitrophenyl group at position 4 is replaced by 1-methyl-2-methylsulfonyl-5-imidazolyl substituent, were synthesized and evaluated as calcium channel antagonists on guinea-pig ileal smooth muscle. Nifedipine was used as a standard. Compound 6n was found to be the most active.

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Year:  1998        PMID： 9700935     DOI： 10.1016/s0031-6865(98)00004-1

Source DB:  PubMed          Journal:  Pharm Acta Helv        ISSN： 0031-6865


  4 in total

1.  Synthesis and cloxacillin antimicrobial enhancement of 2-methylsulfonylimidazolyl-1,4-dihydropyridine derivatives.

Authors:  T Akbarzadeh; A Fallah Tafti; N Samadi; A Foroumadi; M Amanlou; M A Faramarzi; A Shafiee
Journal:  Daru       Date:  2010       Impact factor: 3.117

2.  Nifedipine protects against overproduction of superoxide anion by monocytes from patients with systemic sclerosis.

Authors:  Yannick Allanore; Didier Borderie; Axel Périanin; Hervé Lemaréchal; Ohvanesse Garabed Ekindjian; André Kahan
Journal:  Arthritis Res Ther       Date:  2004-11-16       Impact factor: 5.156

Review 3.  Synthesis and structural activity relationship study of antitubercular carboxamides.

Authors:  D I Ugwu; B E Ezema; F U Eze; D I Ugwuja
Journal:  Int J Med Chem       Date:  2014-12-30

4.  Quantitative Structure-Activity Relationship Studies of 4-Imidazolyl- 1,4-dihydropyridines as Calcium Channel Blockers.

Authors:  Farzin Hadizadeh; Saadat Vahdani; Mehrnaz Jafarpour
Journal:  Iran J Basic Med Sci       Date:  2013-08       Impact factor: 2.699
  4 in total

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