Literature DB >> 9700757

PACAP colocalizes with luteinizing and follicle-stimulating hormone immunoreactivities in the anterior lobe of the pituitary gland.

K Köves1, O Kántor, J G Scammell, A Arimura.   

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP) and its close relative vasoactive intestinal polypeptide (VIP) were demonstrated in the anterior pituitary gland. The cells which exhibited PACAP immunoreactivity were oval or round shaped. Their distribution was similar to that of gonadotropes but the number of PACAP immunoreactive cells was less. Double labeling revealed that PACAP immunoreactivity partially colocalized with luteinizing and follicle-stimulating hormone; however, colocalization with other pituitary hormone immunoreactivities was not demonstrated. Our results suggest an autocrine or paracrine role of PACAP in the regulation of pituitary functions.

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Year:  1998        PMID： 9700757     DOI： 10.1016/s0196-9781(98)00049-7

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  18 in total

Review 1.  Outside the box signaling: secreted factors modulate GnRH receptor-mediated gonadotropin regulation.

Authors:  Hanna Pincas; Soon Gang Choi; Qian Wang; Jingjing Jia; Judith L Turgeon; Stuart C Sealfon
Journal:  Mol Cell Endocrinol       Date:  2013-08-28       Impact factor: 4.102

2.  Targeted pituitary overexpression of pituitary adenylate-cyclase activating polypeptide alters postnatal sexual maturation in male mice.

Authors:  Joseph P Moore; Rong Q Yang; Stephen J Winters
Journal:  Endocrinology       Date:  2012-02-07       Impact factor: 4.736

Review 3.  Paracrinicity: the story of 30 years of cellular pituitary crosstalk.

Authors:  C Denef
Journal:  J Neuroendocrinol       Date:  2008-01       Impact factor: 3.627

4.  GATA augments GNRH-mediated increases in Adcyap1 gene expression in pituitary gonadotrope cells.

Authors:  Robin L Thomas; Natalie M Crawford; Constance M Grafer; Weiming Zheng; Lisa M Halvorson
Journal:  J Mol Endocrinol       Date:  2013-11-07       Impact factor: 5.098

5.  Research resource: Gonadotropin-releasing hormone receptor-mediated signaling network in LbetaT2 cells: a pathway-based web-accessible knowledgebase.

Authors:  Marc Y Fink; Hanna Pincas; Soon Gang Choi; German Nudelman; Stuart C Sealfon
Journal:  Mol Endocrinol       Date:  2010-06-30

Review 6.  PACAP: A regulator of mammalian reproductive function.

Authors:  Stephen J Winters; Joseph P Moore
Journal:  Mol Cell Endocrinol       Date:  2020-06-17       Impact factor: 4.102

Review 7.  PACAP, an autocrine/paracrine regulator of gonadotrophs.

Authors:  Stephen J Winters; Joseph P Moore
Journal:  Biol Reprod       Date:  2010-12-29       Impact factor: 4.285

8.  Androgen receptor drives transcription of rat PACAP in gonadotrope cells.

Authors:  Constance M Grafer; Lisa M Halvorson
Journal:  Mol Endocrinol       Date:  2013-06-24

9.  Developmental changes in pituitary adenylate cyclase activating polypeptide expression during the perinatal period: possible role in fetal gonadotroph regulation.

Authors:  Joseph P Moore; Betty C Villafuerte; Christian A Unick; Stephen J Winters
Journal:  Endocrinology       Date:  2009-07-02       Impact factor: 4.736

10.  GnRH stimulates expression of PACAP in the pituitary gonadotropes via both the PKA and PKC signaling systems.

Authors:  Constance M Grafer; Robin Thomas; Litsa Lambrakos; Ignacio Montoya; Sheryl White; Lisa M Halvorson
Journal:  Mol Endocrinol       Date:  2009-04-02
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