Literature DB >> 970033

Regulation of progesterone biosynthesis in human placental mitochondria by Krebs cycle metabolites.

J Klimek, W Boguslawski, B Tialowska, L Zelewski.   

Abstract

1. 2-Oxoglutarate, succinate, fumarate, malate and citrate, cis-aconitate and isocitrate stimulate conversion of cholesterol to progesterone in human placental mitochondria. 2. The stimulatory effect of dicarboxylic and tricarboxylic acids depends on the activity of malate dehydrogenase (decarboxylating) (NADP+) (EC 1.1.1.40) and isocitrate dehydrogenase (NADP+) (EC 1.1.1.42), respectively.

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Year:  1976        PMID: 970033

Source DB:  PubMed          Journal:  Acta Biochim Pol        ISSN: 0001-527X            Impact factor:   2.149


  1 in total

1.  Subcellular distribution of isocitrate dehydrogenase in early and term human placenta.

Authors:  P W Scisłowski; S Zołnierowicz; L Zelewski
Journal:  Biochem J       Date:  1983-08-15       Impact factor: 3.857

  1 in total

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