Literature DB >> 9699526

Deletion mapping of chromosome 4q in hepatocellular carcinoma.

Z Piao1, C Park, J H Park, H Kim.   

Abstract

Hepatocellular carcinoma (HCC) frequently shows a loss of heterozygosity (LOH) on chromosome 4q. In order to define the commonly affected region on chromosome 4q for further positional cloning of the putative tumor suppressor gene, we carried out allelic imbalance (AI) studies in 41 HCCs using a panel of 43 microsatellite markers. Thirty-four cases (82.9%) showed AI at one or more loci. Detailed deletion mapping identified 7 independent, frequently deleted regions on this chromosome arm. These were the (1) D4S1615 locus, (2) D4S1598 locus, (3) D4S620 locus, (4) D4S1566 and D4S2979 loci, (5) D4S1617 and D4S1545 loci, (6)D4S1537 locus; and (7) from the D4S2920 to D4S2954 locus. Among these 7 frequently deleted regions, 5 were associated with tumor differentiation. Our results suggest that several putative tumor suppressor genes may be present on chromosome 4q and that the AI of chromosome 4q may play a role in the aggressive progression of HCC.

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Mesh：

Year:  1998        PMID： 9699526     DOI： 10.1002/(sici)1097-0215(19980821)79:4<356::aid-ijc8>3.0.co;2-u

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  8 in total

1.  Mapping of genetic deletions on the long arm of chromosome 4 in human esophageal adenocarcinomas.

Authors:  C A Rumpel; S M Powell; C A Moskaluk
Journal:  Am J Pathol       Date:  1999-05       Impact factor: 4.307

2.  LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma.

Authors:  Guo-Liang Huang; Bin-Kui Li; Mei-Yin Zhang; Hui-Zhong Zhang; Rong-Rong Wei; Yun-Fei Yuan; Ming Shi; Xiao-Qian Chen; Long Huang; An-Hua Li; Bi-Jun Huang; Hong-Hua Li; Hui-Yun Wang
Journal:  World J Gastroenterol       Date:  2010-04-28       Impact factor: 5.742

3.  Allelic imbalance regions on chromosomes 8p, 17p and 19p related to metastasis of hepatocellular carcinoma: comparison between matched primary and metastatic lesions in 22 patients by genome-wide microsatellite analysis.

Authors:  Lian-Hai Zhang; Lun-Xiu Qin; Zeng-Chen Ma; Sheng-Long Ye; Yin-Kun Liu; Qing-Hai Ye; Xin Wu; Wei Huang; Zhao-You Tang
Journal:  J Cancer Res Clin Oncol       Date:  2003-05-07       Impact factor: 4.553

4.  Tumor suppress genes screening analysis on 4q in sporadic colorectal carcinoma.

Authors:  Li-Xin Jiang; Jie Xu; Zhao-Wen Wang; Da-Peng Li; Zhi-Hai Peng; Jian-Jun Gao; Lin He; Hai-Tao Zheng
Journal:  World J Gastroenterol       Date:  2008-09-28       Impact factor: 5.742

5.  Chromosomal changes during development and progression of prostate adenocarcinomas.

Authors:  H Zitzelsberger; D Engert; A Walch; U Kulka; M Aubele; H Höfler; M Bauchinger; M Werner
Journal:  Br J Cancer       Date:  2001-01       Impact factor: 7.640

6.  Preferential loss of a polymorphic RIZ allele in human hepatocellular carcinoma.

Authors:  W Fang; Z Piao; I M Buyse; D Simon; J C Sheu; M Perucho; S Huang
Journal:  Br J Cancer       Date:  2001-03-23       Impact factor: 7.640

7.  Establishment and characterization of a novel primary hepatocellular carcinoma cell line with metastatic ability in vivo.

Authors:  Phyllis Fung-Yi Cheung; Chi Wai Yip; Linda Wing-Chi Ng; Kwok Wai Lo; Nathalie Wong; Kwong Wai Choy; Chit Chow; Kui Fat Chan; Tan To Cheung; Ronnie Tung-Ping Poon; Sheung Tat Fan; Siu Tim Cheung
Journal:  Cancer Cell Int       Date:  2014-10-09       Impact factor: 5.722

8.  PTEN / MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas.

Authors:  Y Fujiwara; D S Hoon; T Yamada; K Umeshita; M Gotoh; M Sakon; I Nishisho; M Monden
Journal:  Jpn J Cancer Res       Date:  2000-03
  8 in total

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