Literature DB >> 9699225

CNS effects of a series of 1,2,4-triazolyl heterocarboxylic derivatives.

V Darias1, S Abdala, D Martin-Herrera, M L Tello, S Vega.   

Abstract

A series of 1,2,4-triazolyl heterocarboxylic derivatives were tested for acute toxicity and CNS effects in mice. Several of these compounds demonstrated clear psychostimulant effects. Other components of the series, however, showed a definite central depressant activity. Some of the screened derivatives showed interesting anxiolytic properties.

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Year:  1998        PMID: 9699225

Source DB:  PubMed          Journal:  Pharmazie        ISSN: 0031-7144            Impact factor:   1.267


  8 in total

1.  Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital.

Authors:  Kei Kawada; Tomoaki Ishida; Kohei Jobu; Shumpei Morisawa; Tetsushi Kawazoe; Motoki Nishida; Satomi Nishimura; Naohisa Tamura; Saburo Yoshioka; Mitsuhiko Miyamura
Journal:  J Nat Med       Date:  2022-03-08       Impact factor: 2.343

2.  Ethanol Extract of the Flower Chrysanthemum morifolium Augments Pentobarbital-Induced Sleep Behaviors: Involvement of Cl Channel Activation.

Authors:  Jae-Wook Kim; Jin-Yi Han; Jin Tae Hong; Rihua Li; Jae Soon Eun; Ki-Wan Oh
Journal:  Evid Based Complement Alternat Med       Date:  2011-02-10       Impact factor: 2.629

3.  Gastrodiae Rhizoma Ethanol Extract Enhances Pentobarbital-Induced Sleeping Behaviors and Rapid Eye Movement Sleep via the Activation of GABA A -ergic Transmission in Rodents.

Authors:  Jae Joon Choi; Eun-Hye Oh; Mi Kyeong Lee; Youn Bok Chung; Jin Tae Hong; Ki-Wan Oh
Journal:  Evid Based Complement Alternat Med       Date:  2014-12-30       Impact factor: 2.629

4.  Pachymic Acid Enhances Pentobarbital-Induced Sleeping Behaviors via GABAA-ergic Systems in Mice.

Authors:  Vikash Kumar Shah; Jae Joon Choi; Jin-Yi Han; Mi Kyeong Lee; Jin Tae Hong; Ki-Wan Oh
Journal:  Biomol Ther (Seoul)       Date:  2014-07       Impact factor: 4.634

5.  Potentiation of decursinol angelate on pentobarbital-induced sleeping behaviors via the activation of GABAA-ergic systems in rodents.

Authors:  Jae Hoon Woo; Tae-Woo Ha; Jae-Seon Kang; Jin Tae Hong; Ki-Wan Oh
Journal:  Korean J Physiol Pharmacol       Date:  2016-12-21       Impact factor: 2.016

6.  Study on the hypnotic effect of rare protopanaxadiol-type and protopanaxatriol-type ginsenosides.

Authors:  Ning Mou; Zhiguang Duan; Pei Ma; Rongzhan Fu; Daidi Fan
Journal:  RSC Adv       Date:  2019-07-01       Impact factor: 3.361

7.  Central nervous system depressant activity of Jatamansi (Nardostachys jatamansi DC.) rhizome.

Authors:  Kalpesh Panara; Mukeshkumar Nariya; Nishteswar Karra
Journal:  Ayu       Date:  2022-06-03

8.  5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality.

Authors:  Miriam S N Hohmann; Renato D R Cardoso; Felipe A Pinho-Ribeiro; Jefferson Crespigio; Thiago M Cunha; José C Alves-Filho; Rosiane V da Silva; Phileno Pinge-Filho; Sergio H Ferreira; Fernando Q Cunha; Rubia Casagrande; Waldiceu A Verri
Journal:  Biomed Res Int       Date:  2013-10-31       Impact factor: 3.411

  8 in total

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