Literature DB >> 9697410

Getting knotted: a model for the structure and activation of Spätzle.

K Mizuguchi1, J S Parker, T L Blundell, N J Gay.   

Abstract

Sequence analyses show that Spätzle, the Drosophila melanogaster Toll-receptor ligand, shows striking similarity to nerve growth factor and coagulogen. Comparative modelling suggests that Spätzle adopts a cystine-knot fold and forms a dimer that contains a single, intermolecular disulphide bridge. Proteolytically cleaved Spätzle could therefore dimerize and activate the Toll receptor by inducing receptor dimerization.

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Year:  1998        PMID： 9697410     DOI： 10.1016/s0968-0004(98)01216-x

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  27 in total

Review 1.  Toll receptors: a central element in innate immune responses.

Authors:  Thierry Vasselon; Patricia A Detmers
Journal:  Infect Immun       Date:  2002-03       Impact factor: 3.441

Review 2.  NF-kappaB in the immune response of Drosophila.

Authors:  Charles Hetru; Jules A Hoffmann
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-10-07       Impact factor: 10.005

3.  The origin of dorsoventral polarity in Drosophila.

Authors:  Siegfried Roth
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2003-08-29       Impact factor: 6.237

4.  Molecular mechanism that induces activation of Spätzle, the ligand for the Drosophila Toll receptor.

Authors:  Christopher J Arnot; Nicholas J Gay; Monique Gangloff
Journal:  J Biol Chem       Date:  2010-04-08       Impact factor: 5.157

Review 5.  Transmission, Development, and Plasticity of Synapses.

Authors:  Kathryn P Harris; J Troy Littleton
Journal:  Genetics       Date:  2015-10       Impact factor: 4.562

6.  Crystallization of Spätzle, a cystine-knot protein involved in embryonic development and innate immunity in Drosophila melanogaster.

Authors:  Anita Hoffmann; Piotr Neumann; Angelika Schierhorn; Milton T Stubbs
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-07-05

7.  Differential gene expression in laboratory strains of human head and body lice when challenged with Bartonella quintana, a pathogenic bacterium.

Authors:  D Previte; B P Olds; K Yoon; W Sun; W Muir; K N Paige; S H Lee; J Clark; J E Koehler; B R Pittendrigh
Journal:  Insect Mol Biol       Date:  2014-01-09       Impact factor: 3.585

8.  Cloning and the expression pattern of Spätzle gene during embryonic development and bacterial challenge in Artemia sinica.

Authors:  Lu-Ping Zheng; Lin Hou; Miao Yu; Xiang Li; Xiang-Yang Zou
Journal:  Mol Biol Rep       Date:  2011-12-28       Impact factor: 2.316

9.  Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium.

Authors:  S Frantz; L Kobzik; Y D Kim; R Fukazawa; R Medzhitov; R T Lee; R A Kelly
Journal:  J Clin Invest       Date:  1999-08       Impact factor: 14.808

10.  Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation.

Authors:  Miranda Lewis; Christopher J Arnot; Helen Beeston; Airlie McCoy; Alison E Ashcroft; Nicholas J Gay; Monique Gangloff
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-26       Impact factor: 11.205
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