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Literature DB >> 9696880

Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection.

G Karupiah¹, J H Chen, C F Nathan, S Mahalingam, J D MacMicking.

Abstract

To assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2-/- mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2-/- mice proved highly susceptible to EV yet showed no diminution in other well-characterized anti-EV immune responses, i.e. , gamma interferon secretion and NK cell and EV-specific cytotoxic T lymphocyte activities. Thus, the NOS2 locus can be considered a critical monogenic determinant of EV resistance that contributes to host survival.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1998 PMID： 9696880 PMCID： PMC110049

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

23 in total

1. Mechanisms determining innate resistance to ectromelia virus infection in C57BL mice.

Authors: H C O'Neill; R V Blanden
Journal: Infect Immun Date: 1983-09 Impact factor: 3.441

2. Interferon-gamma induced type I nitric oxide synthase activity inhibits viral replication in neurons.

Authors: T Komatsu; Z Bi; C S Reiss
Journal: J Neuroimmunol Date: 1996-08 Impact factor: 3.478

3. Importance of interferons in recovery from mousepox.

Authors: G Karupiah; T N Fredrickson; K L Holmes; L H Khairallah; R M Buller
Journal: J Virol Date: 1993-07 Impact factor: 5.103

4. Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2.

Authors: G Karupiah; B E Coupar; M E Andrew; D B Boyle; S M Phillips; A Müllbacher; R V Blanden; I A Ramshaw
Journal: J Immunol Date: 1990-01-01 Impact factor: 5.422

5. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase.

Authors: G Karupiah; Q W Xie; R M Buller; C Nathan; C Duarte; J D MacMicking
Journal: Science Date: 1993-09-10 Impact factor: 47.728

6. Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication.

Authors: K D Croen
Journal: J Clin Invest Date: 1993-06 Impact factor: 14.808

7. Genetic determinants of resistance to ectromelia (mousepox) virus-induced mortality.

Authors: G D Wallace; R M Buller; H C Morse
Journal: J Virol Date: 1985-09 Impact factor: 5.103

8. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.

Authors: J D MacMicking; C Nathan; G Hom; N Chartrain; D S Fletcher; M Trumbauer; K Stevens; Q W Xie; K Sokol; N Hutchinson
Journal: Cell Date: 1995-05-19 Impact factor: 41.582

9. Nitric oxide production is increased during murine vaccinia virus infection, but may not be essential for virus clearance.

Authors: M S Rolph; I A Ramshaw; K A Rockett; J Ruby; W B Cowden
Journal: Virology Date: 1996-03-15 Impact factor: 3.616

10. Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice.

Authors: G Karupiah; J H Chen; S Mahalingam; C F Nathan; J D MacMicking
Journal: J Exp Med Date: 1998-10-19 Impact factor: 14.307

19 in total

1. Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.

Authors: R J Jackson; A J Ramsay; C D Christensen; S Beaton; D F Hall; I A Ramshaw
Journal: J Virol Date: 2001-02 Impact factor: 5.103

2. Clearance of HIV type 1 envelope recombinant sendai virus depends on CD4+ T cells and interferon-gamma but not B cells, CD8+ T cells, or perforin.

Authors: Sherri L Surman; Scott A Brown; Bart G Jones; David L Woodland; Julia L Hurwitz
Journal: AIDS Res Hum Retroviruses Date: 2010-07 Impact factor: 2.205

3. Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo.

Authors: Deborah J Lenschow; Nadia V Giannakopoulos; Lacey J Gunn; Christine Johnston; Andy K O'Guin; Robert E Schmidt; Beth Levine; Herbert W Virgin
Journal: J Virol Date: 2005-11 Impact factor: 5.103

4. Nitric oxide inhibits HIV tat-induced NF-kappaB activation.

Authors: F Chen; Y Lu; V Castranova; Y Rojanasakul; K Miyahara; Y Shizuta; V Vallyathan; X Shi; L M Demers
Journal: Am J Pathol Date: 1999-07 Impact factor: 4.307

5. Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.

Authors: Eva-Jasmin Freyschmidt; Clinton B Mathias; Natalia Diaz; Daniel H MacArthur; Amale Laouar; Narasimhaswamy Manjunath; Matthias D Hofer; Marc-Andre Wurbel; James J Campbell; Talal A Chatila; Hans C Oettgen
Journal: J Immunol Date: 2010-06-14 Impact factor: 5.422

10. Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice.

Authors: G Karupiah; J H Chen; S Mahalingam; C F Nathan; J D MacMicking
Journal: J Exp Med Date: 1998-10-19 Impact factor: 14.307

Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection.

1. Mechanisms determining innate resistance to ectromelia virus infection in C57BL mice.

2. Interferon-gamma induced type I nitric oxide synthase activity inhibits viral replication in neurons.

3. Importance of interferons in recovery from mousepox.

4. Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2.

5. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase.

6. Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication.

7. Genetic determinants of resistance to ectromelia (mousepox) virus-induced mortality.

8. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.

9. Nitric oxide production is increased during murine vaccinia virus infection, but may not be essential for virus clearance.

10. Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice.

1. Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.

2. Clearance of HIV type 1 envelope recombinant sendai virus depends on CD4+ T cells and interferon-gamma but not B cells, CD8+ T cells, or perforin.

3. Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo.

4. Nitric oxide inhibits HIV tat-induced NF-kappaB activation.

5. Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.

6. Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus.

7. Interleukin-18 protects mice against acute herpes simplex virus type 1 infection.

8. The interferon-inducible chemokines MuMig and Crg-2 exhibit antiviral activity In vivo.

Review 9. Innate immune control and regulation of influenza virus infections.

10. Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice.