Literature DB >> 9696875

Classical swine fever virus leader proteinase Npro is not required for viral replication in cell culture.

J D Tratschin1, C Moser, N Ruggli, M A Hofmann.   

Abstract

The sequence encoding the viral leader proteinase Npro was replaced by the murine ubiquitin gene in a full-length cDNA clone of the classical swine fever virus (CSFV) strain Alfort/187. The recombinant virus vA187-Ubi showed growth characteristics similar to those of the parent vA187-1 virus. At two occasions cells infected with vA187-Ubi exhibited a cytopathic effect and were found to contain a subgenomic viral RNA. This RNA lacked the same viral genes as the subgenomic RNA which has been found in all cytopathogenic CSFV strains analyzed so far, but it maintained the ubiquitin sequence.

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Year:  1998        PMID： 9696875      PMCID： PMC110041     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  14 in total

1.  Processing of pestivirus polyprotein: cleavage site between autoprotease and nucleocapsid protein of classical swine fever virus.

Authors:  R Stark; G Meyers; T Rümenapf; H J Thiel
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103

2.  Ubiquitin carboxyl-terminal hydrolase acts on ubiquitin carboxyl-terminal amides.

Authors:  C M Pickart; I A Rose
Journal:  J Biol Chem       Date:  1985-07-05       Impact factor: 5.157

3.  Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex.

Authors:  M A Devaney; V N Vakharia; R E Lloyd; E Ehrenfeld; M J Grubman
Journal:  J Virol       Date:  1988-11       Impact factor: 5.103

4.  Nucleotide sequence of classical swine fever virus strain Alfort/187 and transcription of infectious RNA from stably cloned full-length cDNA.

Authors:  N Ruggli; J D Tratschin; C Mittelholzer; M A Hofmann
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

5.  Pathogenesis of mucosal disease: a cytopathogenic pestivirus generated by an internal deletion.

Authors:  N Tautz; H J Thiel; E J Dubovi; G Meyers
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

6.  Pestivirus translation initiation occurs by internal ribosome entry.

Authors:  T L Poole; C Wang; R A Popp; L N Potgieter; A Siddiqui; M S Collett
Journal:  Virology       Date:  1995-01-10       Impact factor: 3.616

7.  Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus.

Authors:  M E Piccone; M Zellner; T F Kumosinski; P W Mason; M J Grubman
Journal:  J Virol       Date:  1995-08       Impact factor: 5.103

8.  The foot-and-mouth disease virus leader proteinase gene is not required for viral replication.

Authors:  M E Piccone; E Rieder; P W Mason; M J Grubman
Journal:  J Virol       Date:  1995-09       Impact factor: 5.103

9.  Polypeptide requirements for assembly of functional Sindbis virus replication complexes: a model for the temporal regulation of minus- and plus-strand RNA synthesis.

Authors:  J A Lemm; T Rümenapf; E G Strauss; J H Strauss; C M Rice
Journal:  EMBO J       Date:  1994-06-15       Impact factor: 11.598

10.  Generation of cytopathogenic subgenomic RNA of classical swine fever virus in persistently infected porcine cell lines.

Authors:  C Mittelholzer; C Moser; J D Tratschin; M A Hofmann
Journal:  Virus Res       Date:  1997-10       Impact factor: 3.303
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  35 in total

1.  Mutations abrogating the RNase activity in glycoprotein E(rns) of the pestivirus classical swine fever virus lead to virus attenuation.

Authors:  G Meyers; A Saalmüller; M Büttner
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

2.  The amino-terminal domain of bovine viral diarrhea virus Npro protein is necessary for alpha/beta interferon antagonism.

Authors:  Laura H V G Gil; Israrul H Ansari; Ventzislav Vassilev; Delin Liang; Vicky C H Lai; Weidong Zhong; Zhi Hong; Edward J Dubovi; Ruben O Donis
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

3.  Mutation of cysteine 171 of pestivirus E rns RNase prevents homodimer formation and leads to attenuation of classical swine fever virus.

Authors:  Birke Andrea Tews; Eva-Maria Schürmann; Gregor Meyers
Journal:  J Virol       Date:  2009-03-04       Impact factor: 5.103

4.  A positively charged surface patch on the pestivirus NS3 protease module plays an important role in modulating NS3 helicase activity and virus production.

Authors:  Fengwei Zheng; Weicheng Yi; Weichi Liu; Hongchang Zhu; Peng Gong; Zishu Pan
Journal:  Arch Virol       Date:  2021-03-31       Impact factor: 2.574

5.  Phylogenetic analysis of NS5B gene of classical swine fever virus isolates indicates plausible Chinese origin of Indian subgroup 2.2 viruses.

Authors:  S S Patil; D Hemadri; H Veeresh; K Sreekala; M R Gajendragad; K Prabhudas
Journal:  Virus Genes       Date:  2011-01-19       Impact factor: 2.332

6.  Classical swine fever virus Npro interacts with interferon regulatory factor 3 and induces its proteasomal degradation.

Authors:  Oliver Bauhofer; Artur Summerfield; Yoshihiro Sakoda; Jon-Duri Tratschin; Martin A Hofmann; Nicolas Ruggli
Journal:  J Virol       Date:  2007-01-10       Impact factor: 5.103

7.  RNA recombination between persisting pestivirus and a vaccine strain: generation of cytopathogenic virus and induction of lethal disease.

Authors:  P Becher; M Orlich; H J Thiel
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

8.  A recombinant classical swine fever virus with a marker insertion in the internal ribosome entry site.

Authors:  C Moser; A Bosshart; J D Tratschin; M A Hofmann
Journal:  Virus Genes       Date:  2001       Impact factor: 2.332

9.  Classical swine fever virus can remain virulent after specific elimination of the interferon regulatory factor 3-degrading function of Npro.

Authors:  Nicolas Ruggli; Artur Summerfield; Ana R Fiebach; Laurence Guzylack-Piriou; Oliver Bauhofer; Catherine G Lamm; Sandro Waltersperger; Keita Matsuno; Luzia Liu; Markus Gerber; Kyung H Choi; Martin A Hofmann; Yoshihiro Sakoda; Jon-Duri Tratschin
Journal:  J Virol       Date:  2008-11-05       Impact factor: 5.103

10.  Characterization of RNA-dependent RNA polymerase activity of CSFV NS5B proteins expressed in Escherichia coli.

Authors:  Ming Xiao; Yujing Wang; Jiakuan Chen; Bo Li
Journal:  Virus Genes       Date:  2003-08       Impact factor: 2.332
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