M M Ibelings1, H A Bruining. 1. Department of Surgery, University Hospital Rotterdam Dijkzigt, The Netherlands.
Abstract
OBJECTIVE: To evaluate the risk of patients in intensive care units (ICU) of becoming infected with methicillin-resistant Staphylococcus aureus (MRSA) and to assess the mortality during a six week follow-up period, compared with patients who developed methicillin-sensitive S. aureus (MSSA) infection. DESIGN: Point prevalence survey. SETTING: 1417 ICU in 17 Western European countries. SUBJECTS: 10038 patients in ICU who were part in the EPIC (European Prevalence of Infection in Intensive Care) Study. MAIN OUTCOME MEASURES: Prevalence of MRSA and MSSA ICU-acquired infections, risk factors, and mortality. RESULTS: On the study day 21% of patients had ICU-acquired infections. The most commonly reported pathogen was Staphylococcus aureus (30%). Overall, 60% of strains of S. aureus were resistant to methicillin (with a wide intercountry variation). The most commonly reported MRSA infections were pneumonia and lower respiratory tract infections. The most important risk factor for MRSA was the length of stay in the ICU. MRSA infection reduced the chance of survival, particularly when it was found in lower respiratory tract infections: the risk of mortality was three times higher in patients with MRSA than in those with MSSA. CONCLUSION: Patients in ICU are at high risk of becoming infected with MRSA. The longer they stay, the higher the risk. Patients with MRSA infections are less likely to survive than those with MSSA.
OBJECTIVE: To evaluate the risk of patients in intensive care units (ICU) of becoming infected with methicillin-resistant Staphylococcus aureus (MRSA) and to assess the mortality during a six week follow-up period, compared with patients who developed methicillin-sensitive S. aureus (MSSA) infection. DESIGN: Point prevalence survey. SETTING: 1417 ICU in 17 Western European countries. SUBJECTS: 10038 patients in ICU who were part in the EPIC (European Prevalence of Infection in Intensive Care) Study. MAIN OUTCOME MEASURES: Prevalence of MRSA and MSSA ICU-acquired infections, risk factors, and mortality. RESULTS: On the study day 21% of patients had ICU-acquired infections. The most commonly reported pathogen was Staphylococcus aureus (30%). Overall, 60% of strains of S. aureus were resistant to methicillin (with a wide intercountry variation). The most commonly reported MRSA infections were pneumonia and lower respiratory tract infections. The most important risk factor for MRSA was the length of stay in the ICU. MRSA infection reduced the chance of survival, particularly when it was found in lower respiratory tract infections: the risk of mortality was three times higher in patients with MRSA than in those with MSSA. CONCLUSION:Patients in ICU are at high risk of becoming infected with MRSA. The longer they stay, the higher the risk. Patients with MRSA infections are less likely to survive than those with MSSA.
Authors: Jo-anne M Salangsang; Lee H Harrison; Maria M Brooks; Kathleen A Shutt; Melissa I Saul; Carlene A Muto Journal: Infect Control Hosp Epidemiol Date: 2010-11 Impact factor: 3.254
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Authors: Marlieke E A de Kraker; Martin Wolkewitz; Peter G Davey; Walter Koller; Jutta Berger; Jan Nagler; Claudine Icket; Smilja Kalenic; Jasminka Horvatic; Harald Seifert; Achim J Kaasch; Olga Paniara; Athina Argyropoulou; Maria Bompola; Edmond Smyth; Mairead Skally; Annibale Raglio; Uga Dumpis; Agita Melbarde Kelmere; Michael Borg; Deborah Xuereb; Mihaela C Ghita; Michelle Noble; Jana Kolman; Stanko Grabljevec; David Turner; Louise Lansbury; Hajo Grundmann Journal: Antimicrob Agents Chemother Date: 2011-01-10 Impact factor: 5.191