Literature DB >> 9695187

Btk function in B cell development and response.

A B Satterthwaite1, Z Li, O N Witte.   

Abstract

Mutations in Bruton's tyrosine kinase (Btk) result in the B cell immunodeficiencies XLA in humans and Xid in mice. Both the maintenance of peripheral B cell numbers and their response to B cell antigen receptor (BCR) crosslinking depend on Btk. Btk integrates signals from multiple cell surface receptors, including BCR and G-protein coupled receptors. These Btk dependent signals control B cell proliferation and survival by mediating Ca2+ flux, activating JNK and p38 and inducing cell cycle regulatory genes.

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Year:  1998        PMID： 9695187     DOI： 10.1006/smim.1998.0123

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   11.130


  40 in total

1.  Posttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells.

Authors:  S Nisitani; A B Satterthwaite; K Akashi; I L Weissman; O N Witte; M I Wahl
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

2.  B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

Authors:  F Loder; B Mutschler; R J Ray; C J Paige; P Sideras; R Torres; M C Lamers; R Carsetti
Journal:  J Exp Med       Date:  1999-07-05       Impact factor: 14.307

Review 3.  X-linked agammaglobulinemia.

Authors:  M E Conley; J Rohrer; Y Minegishi
Journal:  Clin Rev Allergy Immunol       Date:  2000-10       Impact factor: 8.667

4.  Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec.

Authors:  Michael G Tomlinson; Lawrence P Kane; Jennifer Su; Theresa A Kadlecek; Marianne N Mollenauer; Arthur Weiss
Journal:  Mol Cell Biol       Date:  2004-03       Impact factor: 4.272

5.  In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies.

Authors:  S Nisitani; R M Kato; D J Rawlings; O N Witte; M I Wahl
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

6.  Analysis of the Effects of the Bruton's tyrosine kinase (Btk) Inhibitor Ibrutinib on Monocyte Fcγ Receptor (FcγR) Function.

Authors:  Li Ren; Amanda Campbell; Huiqing Fang; Shalini Gautam; Saranya Elavazhagan; Kavin Fatehchand; Payal Mehta; Andrew Stiff; Brenda F Reader; Xiaokui Mo; John C Byrd; William E Carson; Jonathan P Butchar; Susheela Tridandapani
Journal:  J Biol Chem       Date:  2015-12-01       Impact factor: 5.157

7.  Induction of in vivo antipolysaccharide immunoglobulin responses to intact Streptococcus pneumoniae is more heavily dependent on Btk-mediated B-cell receptor signaling than antiprotein responses.

Authors:  Abdul Q Khan; Goutam Sen; Shuling Guo; Owen N Witte; Clifford M Snapper
Journal:  Infect Immun       Date:  2006-02       Impact factor: 3.441

8.  Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes.

Authors:  David A Fruman; Gregory Z Ferl; Sam S An; Amber C Donahue; Anne B Satterthwaite; Owen N Witte
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-26       Impact factor: 11.205

9.  Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene.

Authors:  Peggy L Kendall; Daniel J Moore; Chrys Hulbert; Kristen L Hoek; Wasif N Khan; James W Thomas
Journal:  J Immunol       Date:  2009-10-19       Impact factor: 5.422

10.  A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria.

Authors:  Carolyn Wiltshire; Masato Matsushita; Satoshi Tsukada; David A F Gillespie; Gerhard H W May
Journal:  Biochem J       Date:  2002-11-01       Impact factor: 3.857
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